نتایج جستجو برای: bacterial pathogen

تعداد نتایج: 258155  

2014
Lakshmi A. Narayanan Mariola J. Edelmann

The ubiquitin modification has various functions in the host innate immune system in response to the bacterial infection. To counteract the host immunity, Salmonella can specifically target ubiquitin pathways by its effector proteins. In this review, we describe the multiple facets of ubiquitin function during infection with Salmonella enterica Typhimurium and hypothesize how these studies on t...

Journal: :Omics : a journal of integrative biology 2002
Eugene Kolker Samuel Purvine Alex Picone Tim Cherny Brian J Akerley Robert S Munson Bernhard O Palsson Dayle A Daines Arnold L Smith

Developments in high-throughput analysis tools coupled with integrative computational techniques have enabled biological studies to reach new levels. The ability to correlate large volumes of diverse data types into cohesive models of organism function has spawned a new systematic approach to biological investigation. The creation of a new consortium has been proposed to investigate a single or...

Journal: :Developmental and comparative immunology 2011
Alejandro Romero Sonia Dios Laura Poisa-Beiro Maria M Costa David Posada Antonio Figueras Beatriz Novoa

In this paper, we describe sequences of fibrinogen-related proteins (FREPs) in the Mediterranean mussel Mytilus galloprovincialis (MuFREPs) with the fibrinogen domain probably involved in the antigen recognition, but without the additional collagen-like domain of ficolins, molecules responsible for complement activation by the lectin pathway. Although they do not seem to be true or primive fico...

Journal: :Journal of Proteome Research 2021

In the context of bacterial infections, it is imperative that physiological responses can be studied in an integrated manner, meaning a simultaneous analysis both host and pathogen responses. To improve sensitivity detection, data-independent acquisition (DIA)-based proteomics was found to outperform data-dependent (DDA) workflows identifying quantifying low-abundant proteins. Here, by making u...

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