Dickinson, Eva, Recep Tuncer, Evan Nadler, Patricia Boyle, Sean Alber, Simon Watkins, and Henri Ford. NOX, a novel nitric oxide scavenger, reduces bacterial translocation in rats after endotoxin challenge. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G1281–G1287, 1999.— Endotoxemia promotes gut barrier failure and bacterial translocation (BT) by upregulating inducible nitric oxide syn...

This study was conducted to investigate impacts of dietary protein levels on gut bacterial community and gut barrier. The intestinal microbiota of finishing pigs, fed with 16%, 13% and 10% crude protein (CP) in diets, respectively, were investigated using Illumina MiSeq sequencing. The ileal bacterial richness tended to decrease when the dietary protein concentration reduced from 16% to 10%. Th...

Recent studies have demonstrated that melatonin significantly decreased all studied acute pancreatitis-associated inflammatory parameters, in addition to reducing apoptosis and necrosis associated with pancreatic injury. However, the effect of melatonin on gut barrier dysfunction and bacterial translocation has not been fully elucidated. This study aimed to investigate the protective effects of...

Neonatal necrotizing enterocolitis (NEC) is a major cause of morbidity in preterm infants. We hypothesize that the intestinal injury in this disease is a consequence of synergy among three of the major risk factors for NEC: prematurity, enteral feeding, and bacterial colonization. Together these factors result in an exaggerated inflammatory response, leading to ischemic bowel necrosis. Human mi...

background and objectives:infection of pleural fluid is a common disease and because of antibiotic administration, the microbiology of this fluid has changed. the aim of this study was to determine the common bacteria and suitable antibiotics for treatment in pleural effusion (pe). materials and methods: in this cross sectional study, 1210 samples with exudative features were cultured for poss...

despite recent innovations in the laboratory diagnosis of bacterial from nonbacterial meningitis, solid data-necessary for early determination of bacterial meningitis (bm) before organism growth in the culture medium-are missing. therefore cerebrospinal fluid (csf) lactate levels were evaluated as a possible means of differentiating the two clinical entities. this was a retrospective study. pat...

Intestinal mucosal injury occurs after remote trauma although the mechanisms that sense remote injury and lead to intestinal epithelial disruption remain incompletely understood. We now hypothesize that Toll-like receptor 4 (TLR4) signaling on enterocytes after remote injury, potentially through the endogenous TLR4 ligand high-mobility group box-1 (HMGB1), could lead to intestinal dysfunction a...

Dickinson, Eva, Recep Tuncer, Evan Nadler, Patricia Boyle, Sean Alber, Simon Watkins, and Henri Ford. NOX, a novel nitric oxide scavenger, reduces bacterial translocation in rats after endotoxin challenge. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G1281–G1287, 1999.— Endotoxemia promotes gut barrier failure and bacterial translocation (BT) by upregulating inducible nitric oxide syn...

Invasion of nonphagocytic cells, a critical property of Listeria monocytogenes (Lm) that enables it to cross host barriers, is mediated by the interaction of two bacterial surface proteins, InlA and InlB, with their respective receptors E-cadherin and c-Met. Although InlA-E-cadherin interaction is necessary and sufficient for Lm crossing of the intestinal barrier, both InlA and InlB are require...

background: coordination is a critical factor in successful organization and appropriate response to disasters. in this regard, a centralized coordination mechanism is the first step towards an effective, efficient, and sustainable response in order to be ensured of the short- and long-term recovery. thus, this study aimed to identify and prioritize the barriers and facilitators of coordination...