Cancer is one of the three biggest causes death in world. The development new drugs against this disease a serious study that must be carried out order to reduce mortality and extend life span sufferers. aim research was develop anti-cancer drug based on halogenated imidazole chalcones have been conducted. A 18 chalcone compound designed performed molecular docking. Potential compounds docking ...

AIMS AND BACKGROUND To assess the diagnostic accuracy of stereotactic vacuum-assisted biopsy of nonpalpable breast lesions. METHODS AND STUDY DESIGN 769 consecutive vacuum-assisted biopsy procedures were retrospectively reviewed. Positive predictive value for carcinoma (B5) at vacuum-assisted biopsy was assessed on the overall series and by age, lesion morphology and size, degree of suspicion...

s of papers 7 25 Alloantigen system L affects antibody responses. Z. O. Medarova*1, W. E. Briles2, and R. L. Taylor, Jr.1, 1Department of Animal and Nutritional Sciences, University of New Hampshire, Durham, NH 03824, 2Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115. Alloantigen system L encodes a polymorphic 135kD protein expressed on the surface of chicken er...

Following the observation of two fraternal patients without neurologic symptoms. but with hereditary methemoglobinemia due to cytochrome b5 reductase deficiency in erythrocytic and nonerythrocytic cells. a familial study of their paternal and maternal relatives was undertaken. Ferrihemoglobin reductase activities in erythrocytes from the two patients were found to be impaired. and cytochrome b5...

The influence of a standardized pollen extract (Cernitin) on the hepatic cytochrome P-450 system was studied in rats chronically exposed to an aerosol of ammonium fluoride. The content of cytochrome P-450 and cytochrome b5 and the activities of NADPH-cytochrome c reductase, aminophenazone N-demethylase, and aniline hydroxylase were determined. After 3 months the content of cytochrome b5 in the ...

Specific metabolic roles of P450-dependent monooxygenase systems are determined by enzymatic properties and substrate specificity of P450s, the terminal enzymes of the electron transfer chain. On the other hand, molecular diversity has also been reported for NADPH-cytochrome P450 reductase, cytochrome b5, and cytochrome b5 reductase in plants. Several lines of evidence indicate that the electro...

256 words Introduction 473 words Discussion – 1238 words d) List of non-standard abbreviations: CYP, cytochrome P450; b5, cytochrome b5; AUC, area under the plasma concentration time curve; ki, reversible inhibition constant; kdeg, rate constant for enzyme degradation; kinact, the maximal rate constant for inactivation; KI, inactivator This article has not been copyedited and formatted. The fin...

Two-dimensional 1H NMR spectroscopy is used to examine the structure and mobility of cytochrome b5 in solution. The assignment of many residues and the interpretation of nuclear Overhauser effects (NOEs) in both redox states allow definition of secondary structural elements. Comparison with X-ray diffraction data shows that differences between crystal and solution structures are small. The dyna...