The objective of this study was to compare the effects of a b3-adrenoceptor (b3-AR) agonist on bladder function and cardiovascular parameters in rats with those of several drugs that act on smooth muscle. CL316,243 (b3-AR agonist), isoproterenol (nonselective b-AR agonist), procaterol (b2-AR agonist), verapamil (Ca antagonist), and papaverine (antispastic drug) each evoked a concentration-depen...

Psoriasis Vulgaris is a complex multifactorial dermatological disease, with various genetic and environmental factors implicated in the onset progression of disease comorbidities. Cardiovascular (CVD) metabolic syndrome are essential psoriasis comorbidities that suggest potential hypercoagulable background disease. To better understand link between psoriasis, hypercoagulation comorbidities, we ...

Here we report a familial cluster of 3 cases of coxsackievirus B3 infection: a recent history of illness in a woman's 3-year-old son with a coxsackievirus B3-positive stool culture indicated that he probably infected his mother at home during her last week of pregnancy. Consequently, she delivered an infected neonate who developed severe hepatitis, disseminated intravascular coagulation, and bi...

Many neuromuscular and central synapses exhibit activity-dependent plasticity. The sustained high-frequency firing needed to elicit some forms of plasticity are similar to those often required to release neuropeptides. We wanted to determine if neuropeptide release could contribute to post-tetanic potentiation (PTP) and chose neuromuscular synapses in buccal muscle I3a to explore this issue. Th...

Objetivo. El Síndrome de caídas es un componente otro, la fragilidad. Establecer fragilidad física en personas mayores con índice Eichner B y C, portadores prótesis removibles defectuosas.Métodos. Estudio descriptivo transversal, adscrito a proyecto Fondo Nacional Investigación Salud (FONISSA20I0052) Chile, defectuosas. Investigaciones demostraron que el equilibrio dinámico, medido prueba timed...

The azoospermia factor c (AZFc) region on the Y chromosome is a genetically dynamic locus in the human genome. Numerous genomic rearrangements, including deletion, duplication and inversion, have been identified in AZFc. The complete deletion of AZFc can cause spermatogenic impairment. However, the roles of partial AZFc deletions (e.g. b2/b3 deletion) in spermatogenesis are controversial and va...

Plexins are the primary receptors of semaphorins, and participate in the majority of intracellular pathways triggered by semaphorins, including the regulation of cell adhesion and the motility of numerous cell types. Recently, several studies have reported that plexins can significantly affect different aspects of cancer cell biology, and the aberrant expression of plexins has been observed in ...