The transmembrane protein ephrin-B2 regulates angiogenesis, i.e. the formation of new blood vessels through endothelial sprouting, proliferation and remodeling processes. In addition to essential roles in the embryonic vasculature, ephrin-B2 expression is upregulated in the adult at sites of neovascularization, such as tumors and wounds. Ephrins are known to bind Eph receptor family tyrosine ki...

In a preceding report of ours1 we demonstrated an impaired intestinal absorp tion of 57CoB12 in vitamin B2 deficient rats and that this impairment of 57CoB12 absorption might be due to a deficiency of intrinsic factor caused by vitamin B2 deficiency. In 1963 Hsu2 made a detailed investigation upon intestinal absorption of 60CoB12 in rats with deficiency of other vitamins than vitamin B12 and co...

Previously, we demonstrated that the level of BCL2 expression is prognostic in acute myelogenous leukemia (AML). High levels of BCL2 correlate with an adverse outcome when associated with favorable and intermediate prognosis cytogenetics (FIPC), whereas low levels portend an adverse outcome when associated with unfavorable cytogenetics (UC). Because BCL2 function can be modulated by dimerizatio...

We investigated the mechanisms by which transforming growth factor (TGF)-b2 inhibited prolactin mRNA expression in GH3 rat pituitary tumor cells. Maximal inhibition was observed with cells exposed to 5 ng/ml TGF-b2 for 24 hr. Continuous presence of the hormone during the entire period was not necessary because exposure of cells to TGF-b2 for 20 min was sufficient to trigger the same extent of p...

Hemp adaptability through physiological and biochemical changes was studied under 10 LED light spectra natural in a controlled aeroponic system. Light treatments were imposed on 25 days aged seedlings for 16 h daily (300 µmol m?2 s?1) 20 days. Plant accumulated highest Cannabidiol (CBD) R7:B2:G1 treatment, with relatively higher photosynthetic rate lower reactive oxygen species, total phenol co...

Calystegines were isolated from the root cultures of Physalis divaricata, P. pubescens, P. philadelphia,and P. philadelphia (solanaceae). Calystegines of P. divaricata were identified as calystegine A3, A5, B1 and B2, with concentrations of 6.99, 4.41, 8.52, and 14.7 ?g/g in fresh mass, respectively. Root cultures of P.pubescens contain calystegine A3, B1 and B2, P. philadelphia only contains ...

b2-Glycoprotein I (b2-GPI), also known as apolipoprotein H, is a 50 kDa protein that was described for the first time in 1961, and in 1968 the first apparently healthy person was identified deficient in this protein. As no function could be attributed to b2-GPI, the protein did not receive much attention and on average a single publication per year appeared in the literature. From 1990 onwards,...

Can Knockout Mice Help Dissect Relevant Genes in Hypertension? Evidence and Confounding Factors To the Editor: In a recent article, Rhaleb et al1 showed that bradykinin B2 receptor gene knockout (B2-KO) mice at 2 to 3 months of age have normal basal blood pressure (BP) levels and heart weight compared with control 129/SvEV Tac mice. In addition, they did not find any difference between B2-KO mi...

Background & Aims: The most significant cause of infertility in men is the genetic deletion in the azoospermia factor (AZF) region that is caused by the process of intra- and inter-chromosomal homologous recombination in amplicons. Homologous recombination could also result in partial deletions in AZF region. The aim of this research was to determine the association between the partial AZFc del...