Skin involvement can be the initial symptom of hematologic malignancies in children (1). Cutaneous involvement in children with acute lymphoblastic leukemia (ALL) is very rare condition compared to acute myeloblastic leukemia (AML). Cutaneous infiltrates in children with acute monocytic leukemia is well-known (2). Scant information is available concerning the occurrence and natural history of s...

B lymphoblastic leukemia (B-ALL) may be associated with recurrent cytogenetic and molecular abnormalities. We describe the fourth-known case of B-ALL associated with the t(8;22)(p11.2q11.2) – a translocation seen more frequently in T lymphoblastic leukemia and acute myelogenous leukemia. This patient’s leukemia involves a combination of additional cytogenetic anomalies not yet described in the ...

acute lymphoblastic leukemia (all) is the most common form of childhood cancer representing 80-85% of all leukemia. we describe a 3 years old girl with pain, swelling and tenderness in extremities since 8 months prior to her present admission. x-ray of extremities revealed callus formation, osteopenia and site of healed fractures. bone marrow aspiration revealed all-l2 with normal peripheral sm...

Leukemia in the newborn is an infrequent disease that has not been well defined using modern laboratory techniques. We describe two infants, one at birth and one at four weeks, with acute lymphoblastic leukemia. The blasts from each patient were studied in great detail, using a battery of cytochemical and immunologic procedures in addition to ultrastructural studies. Immunologic cell marker stu...

Intracellular lactate dehydrogenase (LD) isoenzyme patterns were studied in the malignant cells of patients with a variety of lymphoid malignancies. These were compared with intracellular LD isoenzyme patterns of normal lymphoid cells and were also correlated with immunologic cell surface marker characteristics. Results showed that, in general, the malignant B cells of Burkitt's lymphoma and th...

background: the purpose of this study was to evaluate long-term changes in bone density profile among survivors of childhood acute lymphoblastic leukemia. patients and methods: this was a 5 year prospective study comprised of thirty-one survivors of childhood acute lymphoblastic leukemia with a mean age of 11.8 (4.6) years, who completed therapy at least 1 year previously (according to the all-...

BACKGROUND In a study of childhood acute lymphoblastic leukemia (CoALL 06-97 study), the in vitro sensitivity of the patients' cells to prednisolone, vincristine and asparaginase was introduced as a new additional risk parameter for treatment stratification. In parallel in vivo treatment response was assessed by determining the presence and extent of minimal residual disease in a subset of pati...

acute leukemias represent approximately 30% of malignant diseases in patients under the age of 15 years. leukemic infiltration of the central nervous system and testis are common events, particularly as sites of relapse in the third year after diagnosis. management of acute lymphoblastic leukemia is based on long-term chemotherapy, leading to a cure rate of approximately 80% of children and ado...

Sulforaphane is a dietary isothiocyanate found in cruciferous vegetables showing antileukemic activity. With the purpose of extending the potential clinical impact of sulforaphane in the oncological field, we investigated the antileukemic effect of sulforaphane on blasts from patients affected by different types of leukemia and, taking into account the intrinsically hypoxic nature of bone marro...