A stereoselective synthetic route is reported for the introduction of side chains at the 3-position of trans-2-aminocyclopentanecarboxylic acid (ACPC). Ring opening of the aziridine 2-benzyloxymethyl-6-azabicyclo[3.1.0]hexane with selected nucleophiles occurs in a regioselective manner and provides ACPC precursors with functional groups at the 3-position, trans to the 2-amino group. Oligomers c...

3-Aryl-2H-azirines react with acylketenes, generated by thermolysis of 5-arylfuran-2,3-diones, to give bridged 5,7-dioxa-1-azabicyclo[4.4.1]undeca-3,8-diene-2,10-diones and/or ortho-fused 6,6a,12,12a-tetrahydrobis[1,3]oxazino[3,2-a:3',2'-d]pyrazine-4,10-diones. The latter compounds, with a new heterocyclic skeleton, are the result of the coupling of two molecules of azirine and two molecules of...

Bicyclic nitroxyl derivatives, such as 2-azaadamantane N-oxyl (AZADO) and 9-azabicyclo[3.3.1]nonane N-oxyl (ABNO), have emerged as highly effective alternatives to TEMPO-based catalysts for selective oxidation reactions (TEMPO = 2,2,6,6-tetramethyl-1-piperidine N-oxyl). Their efficacy is widely attributed to their smaller steric profile; however, electrocatalysis studies described herein show t...

CP-45,899 [3,3-dimethyl-7-oxo-4-thia-l-azabicyclo(3,2,0)heptane-2-carboxylic acid, 4,4dioxide, [2S-(2a,5a)]] has low intrinsic activity against most Gram-positive cocci, Enterobacteriaceae and Pseudomona . It inhibits Neisseria at concentrations of 0.1 -6.2 lig/ml. The combination of CP-45,899 and ampicillin inhibited Staphylococcus aureus and En tero bacteriaceae resistant to ampicillin by vir...

This paper introduces a joint industries–academia–academia research project started by researchers in several automobile companies and universities working on single theme. Our first target was to find zeolite for NH3-SCR, that is, mining. Zeolite AFX, having the same topology of SSZ-16, found be one zeolites. SSZ-16 can synthesized using an organic structure-directing agent such as 1,1?-tetram...

A new pentacyclic (5/6/6/6/7) Lycopodium alkaloid named isopalhinine A (1), which possesses a sterically congested architecture built with a tricyclo[4.3.1.0]decane (isotwistane) moiety and a 1-azabicyclo[4.3.1]decane moiety, and palhinines B (2) and C (3) were isolated from Palhinhaea cernua. The structure and absolute configuration of 1 were elucidated by a combination of NMR spectra, optical...