نتایج جستجو برای: autosomal dominant polycystic kidney disease
تعداد نتایج: 1745479 فیلتر نتایج به سال:
AIM To define specific manifestations of autosomal dominant polycystic kidney disease in kidney transplant patients. METHODS Of 874 consecutive first renal transplant patients 1985-1993, 114 (13%) had autosomal dominant polycystic kidney disease (ADPKD). Mean age was 53 +/- 8 years, 62% were men, and 83% received cadaveric kidneys. Control patients were matched for sex, age and donor type. Me...
Renal tubular cysts arise in several inherited human disorders which include autosomal dominant polycystic kidney disease (ADPKD), as well as rarer disorders such as autosomal recessive polycystic kidney disease (ARPKD) nephronophthisis and medullary cystic kidney. Despite their genetic, clinical and histopathological heterogeneity, all these diseases involve a dilation of tubules leading to cy...
SG The more common form of PLD is an extrarenal manifestation of autosomal dominant polycystic kidney disease. The less common form of isolated PLD is an autosomal dominant inherited condition and has been associated with 2 distinct mutations: the PRKCSH gene that encodes for hepatocystin and the SEC63 gene that encodes for a component of the protein translocation machinery in the endoplasmic r...
BACKGROUND In autosomal dominant polycystic kidney disease (ADPKD), aberrant activation of the mammalian target of rapamycin (mTOR) pathway is associated with progressive kidney enlargement. The drug sirolimus suppresses mTOR signaling. METHODS In this 18-month, open-label, randomized, controlled trial, we sought to determine whether sirolimus halts the growth in kidney volume among patients ...
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