Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease of presumed autoimmune etiology affecting predominantly middle-aged women; it is a slowly progressive disease causing loss of intrahepatic bile ducts, resulting in advanced fibrosis, cirrhosis, and liver failure. Many drugs have been studied for treatment, including agents with choleretic and immunosuppressive properties. Ur...

background there is limited data on the natural history of autoimmune hepatitis (aih) and on the long-term follow-up of aih patients who have been referred for regular medical attention. objectives we evaluated the clinical presentation and natural history of aih in a large cohort of type i aih patients from iran. patients and methods between 1997 and 2008, 102 patients were enrolled in the stu...

background liver transplantation (lt) is the only treatment option for patients with advanced liver disease. currently, liver donation to these patients, considering priorities, is based on the model for end-stage liver disease (meld). meld score is a tool for predicting the risk of mortality in patients with advanced liver disease. however, few studies have so far been conducted in iran on the...

Celiac disease (CD) is characterized by sensitivity to gluten, which is found in dietary wheat, barley, and rye. Many extra-intestinal manifestations have been described in association with CD. Liver disease and CD share widespread risk factors. Liver disorders such as autoimmune hepatitis, elevation of liver enzyme levels, primary biliary cirrhosis, nonspecific hepatitis, primary sclerosing ch...

Autoimmune hepatitis also known as Lupoid hepatitis is an autoimmune liver disease characterized by the presence of autoantibodies including antinuclear antibodies (ANA) and hyper gammaglobulinemia. SLE can be associated with hepatitis, which is referred to as lupus hepatitis. It is important to distinguish these two entities, as the course of the disease is different in both. It has also been ...

non-alcoholic steatohepatitis (nash) is a disease of unknown origin characterized histologically by alcoholic-like liver injury in the absence in the absence of significant alcohol intake. this study was conducted to assess the clinical and pathological features of nash patients in iran. patients with elevated liver transaminases, negative serologic markers of viral or autoimmune hepatitis and ...

De novo autoimmune hepatitis (AIH) is a clinical disease similar to AIH that develops in liver transplant recipients with diseases other than AIH. Timely recognition of this makes it possible avoid graft rejection and re-transplantation (LT), fibrosis, can ensure long life expectancy, given the effectiveness more active immunosuppression use corticosteroids azathioprine, as treatment idiopathic...

Reactive lymphoid hyperplasia (RLH) of the liver is a rare and benign nodular lesion. It remains difficult to distinguish RLH from hepatocellular carcinoma (HCC) despite recent advances in imaging modalities. We report five cases of RLH that required differential diagnosis of HCC preoperatively. These cases all occurred in middle-aged women and were associated with autoimmune disease in 40% (2/...

aim : the aim of this study was to review our experience with gestations in autoimmune hepatitis patients. background : there are only limited data describing pregnancy in patients with autoimmune hepatitis. patients and methods : retrospective analysis of pregnancies with autoimmune hepatitis followed in centro hospitalar do porto, portugal in the last ten years. results : we reported nine pre...