Collectively, autoimmune diseases constitute a major, unmet, clinical challenge. Although no single autoimmune disorder is highly prevalent, there are over 80 of them, and 20% of the population is aVected; approximately 75% of patients are women. Because these diseases are generally incurable and diYcult to manage, there is a pressing need for novel approaches to their treatment. For reasons de...

Background: Type 1 Diabetes (T1D) is a chronic and progressive autoimmune disorder. Cytokines play a critical role in the pathogenesis of T1D.   Objective: IFN-¹ polymorphism was investigated in T1D and compared with normal controls.   Methods: Thirty patients suffering from T1D and 40 normal controls were studied simultaneously using PCR technique. IFN-   ¹ gene was evaluated at position 5’UTR...

aim : we described two case reports of aih/ssc overlap syndrome and reviewed literatures regarding this issue.   background : aih is a chronic hepatitis of unknown aetiology characterized by continuing hepatocellular necrosis and inflammation. aih overlap syndromes have been reported with other autoimmune diseases. patients and methods : according to the classification criteria for ssc, we cond...

Landegren, N. 2015. Biomarker Discovery in Tissue-specific Autoimmune Disease. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1153. 56 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9391-2. Autoimmune diseases encompass a diverse group of disorders that collectively affect 5% of the population. Despite large clinical variability, autoimmune d...

Systemic Lupus Erythematosus (SLE) is a multi-systemic autoimmune disorder. Fifty percent will have gastro intestinal symptoms and 1 to 4% jaundice. Two Filipino adolescents with uncommon presentation of SLE are reported: 14-year old female intermittent epigastric pain 17-year male jaundice. Epigastric jaundice presentations in patients SLE. A high index suspicion needed must be considered th...

Chronic Urticaria (CU) is a skin disorder characterized by wheal and flare with duration of more than 6 weeks affecting 1%-2% the population (more common in women). Thirty to 35% cases CU have angioedema [1]. The etiology chronic spontaneous urticarial not usually clear, 40%-50% are idiopathic 30%-40% autoimmune [2, 3]. Quality life disturbed which has direct relation severity [4].

anti-n-methyl-d-aspartate-receptor (nmda-r) encephalitis is a new autoimmune disorder, often paraneoplastic in nature, presenting with complex neuropsychiatric symptoms. diagnosed serologically, this disorder is often responsive to immunosuppressant treatment. we here in report the case of a 56-year-old man with anti nmda-r encephalitis presenting initially with disorientation and hallucination...

Background Autoimmune hemolytic anemia is a hematologic disorder that is rarely observed in infants and young children. Most of the cases are associated with viral or bacterial infections. In some cases, AIHA can be characterized by a chronic course and an unsatisfactory control of hemolysis, thus requiring prolonged immunosuppressive therapy. Case report Especially in children younger...

Autoimmune hepatitis is characterized by inflammation in liver histology, circulating autoantibodies, and increased levels of immunglobulin G, the absence a known etiology. There are different clinical types described children. Because presentation autoimmune with findings, establishment diagnosis may be difficult. In last two decades, 6-fold increase incidence has been reported thanks to updat...