نتایج جستجو برای: autoantibody

تعداد نتایج: 6541  

Journal: :Hypertension 2013
Athar H Siddiqui Roxanna A Irani Weiru Zhang Wei Wang Sean C Blackwell Rodney E Kellems Yang Xia

Preeclampsia (PE) is a life-threatening hypertensive disorder during pregnancy associated with decreased circulating aldosterone levels. However, the molecular mechanisms underlying aldosterone reduction in PE remain unidentified. Here we demonstrate that reduced circulating aldosterone levels in preeclamptic women are associated with the presence of angiotensin II type 1 receptor agonistic aut...

2016
Tineke J. van Wesemael Sofia Ajeganova Jennifer Humphreys Chikashi Terao Ammar Muhammad Deborah P. M. Symmons Alex J. MacGregor Ingiäld Hafström Leendert A. Trouw Annette H. M. van der Helm-van Mil Tom W. J. Huizinga Tsuneyo Mimori René E. M. Toes Fumihiko Matsuda Björn Svensson Suzanne M. M. Verstappen Diane van der Woude

BACKGROUND The contribution of smoking to rheumatoid arthritis (RA) is hypothesized to be mediated through formation of anti-citrullinated protein antibodies (ACPA). In RA, however, autoantibodies such as ACPA, rheumatoid factor (RF), and anti-carbamylated protein antibodies (anti-CarP) often occur together, and it is thus unclear whether smoking is specifically associated with some autoantibod...

2014
Omri Snir David Gomez-Cabrero Ariana Montes Eva Perez-Pampin Juan J Gómez-Reino Maria Seddighzadeh Katharina U Klich Lena Israelsson Bo Ding Anca I Catrina Rikard Holmdahl Lars Alfredsson Lars Klareskog Jesper Tegnér Antonio Gonzalez Vivianne Malmström Leonid Padyukov

INTRODUCTION Genetic susceptibility to complex diseases has been intensively studied during the last decade, yet only signals with small effect have been found leaving open the possibility that subgroups within complex traits show stronger association signals. In rheumatoid arthritis (RA), autoantibody production serves as a helpful discriminator in genetic studies and today anti-citrullinated ...

2016
Alexandra Fouts Laura Pyle Liping Yu Dongmei Miao Aaron Michels Jeffrey Krischer Jay Sosenko Peter Gottlieb Andrea K. Steck

OBJECTIVE To explore whether electrochemiluminescence (ECL) assays can help improve prediction of time to type 1 diabetes in the TrialNet autoantibody-positive population. RESEARCH DESIGN AND METHODS TrialNet subjects who were positive for one or more autoantibodies (microinsulin autoantibody, GAD65 autoantibody [GADA], IA-2A, and ZnT8A) with available ECL-insulin autoantibody (IAA) and ECL-G...

2016
Kendra Vehik Kristian F. Lynch Desmond A. Schatz Beena Akolkar William Hagopian Marian Rewers Jin-Xiong She Olli Simell Jorma Toppari Anette-G. Ziegler Åke Lernmark Ezio Bonifacio Jeffrey P. Krischer

OBJECTIVE β-Cell autoantibodies are a feature of the preclinical phase of type 1 diabetes. Here, we asked how frequently they revert in a cohort of children at risk for type 1 diabetes and whether reversion has any effect on type 1 diabetes risk. RESEARCH DESIGN AND METHODS Children were up to 10 years of age and screened more than once for insulin autoantibody, GAD antibody, and insulinoma a...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Asaf Madi Inbal Hecht Sharron Bransburg-Zabary Yifat Merbl Adi Pick Merav Zucker-Toledano Francisco J Quintana Alfred I Tauber Irun R Cohen Eshel Ben-Jacob

The immune system is essential to body defense and maintenance. Specific antibodies to foreign invaders function in body defense, and it has been suggested that autoantibodies binding to self molecules are important in body maintenance. Recently, the autoantibody repertoires in the bloods of healthy mothers and their newborns were studied using an antigen microarray containing hundreds of self ...

2014
Kourtney Trudgen Nada H. Khattar Eric Bensadoun Susanne Arnold Arnold J. Stromberg Edward A. Hirschowitz

Recommendations for lung cancer screening present a tangible opportunity to integrate predictive blood-based assays with radiographic imaging. This study compares performance of autoantibody markers from prior discovery in sample cohorts from two CT screening trials. One-hundred eighty non-cancer and 6 prevalence and 44 incidence cancer cases detected in the Mayo Lung Screening Trial were teste...

Journal: :The Journal of Experimental Medicine 1985
R Kofler D J Noonan D E Levy M C Wilson N P Møller F J Dixon A N Theofilopoulos

The mRNAs encoding heavy and light chains of a hybridoma-derived monoclonal IgM kappa anti-DNA autoantibody from lupus-prone MRL/Mp-lpr/lpr mice (Ighj) have been transcribed into cDNA copies and molecularly cloned, and their complete nucleotide sequences have been determined. The mRNA for the heavy chain variable region, including leader peptide and 5' untranslated region, is transcribed from a...

2015
Qing Zhu Su-Xia Han Cong-Ya Zhou Meng-Jiao Cai Li-Ping Dai Jian-Ying Zhang

PURPOSE To determine the role of autoantibodies to PARP1 and BRCA1/BRCA2 which were involved in the synthetic lethal interaction in cancer. METHODS Enzyme-Linked Immunosorbent Assay (ELISA) was used to detect autoantibodies to PARP1 and BRCA1/BRCA2 in 618 serum samples including 131 from breast cancer, 94 from lung cancer, 34 from ovarian cancer, 107 from prostate cancer, 76 from liver cancer...

Journal: :Revue francaise de transfusion et immuno-hematologie 1975
S C Ng

สวนใหญการเตรียมเลือดใหผูปวยมักไมพบปญหาใดๆ จึง ทําาใหผูปวยไดรับเลือดตามตองการ และไมเสียเวลาในการรอ เลือด คงมีผูปวยเพียงสวนนอยเทานั้นที่ตรวจพบวามี positive antibody screening และ/หรือ positive crossmatching ซึ่ง ทําาใหเกิดความลาชาในการใหเลือดแกผูปวย เพราะจะตองทําาการ ตรวจเพิ่มเติมเพื่อหาสาเหตุ การตรวจใชเวลาแตกตางกันขึ้นกับ ชนิดของแอนติบอดีที่ตรวจพบวาเปน alloantibody หรือ autoan...

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