The His-x-Asp (HxD) motif is one of the most conserved structural components of the catalytic core of protein kinases; however, the functional role of the conserved histidine is unclear. Here we report that replacement of the HxD-histidine with Arginine or Phenylalanine in Aurora A abolishes both the catalytic activity and auto-phosphorylation, whereas the Histidine-to-tyrosine impairs the cata...

CONTEXT AND OBJECTIVE Fine-needle aspiration biopsy has been accepted worldwide for breast lesions. However, some questions remain, including the appropriateness of the puncture method. The objective of this work was to compare aspirates obtained by the auto-vacuum device and by the syringe pistol holder. DESIGN AND SETTING Randomized trial for validation of diagnostic method, at Hospital das...

Non-motorized vehicles (i.e. rickshaws) and small size motorized vehicles (i.e. auto-rickshaws) are popular para-transit modes that provided door-to-door service in congested parts of Dhaka metropolitan area. Improper design of signal timing at signalized intersections is one of the reasons of traffic congestion in Dhaka metropolitan area. For capacity analysis, to convert the mixed traffic flo...

this experiment was conducted to evaluate the effects of supplemental l-arginine (arg) in reduced-protein diets on cardiopulmonary performance and intestinal morphology in the broilers reared at high altitude. a total of 156 day-old male broilers were randomly assigned to 3 treatments and 4 replicates of 13 chicks and reared up to 42 days of age. treatment groups were designed as a normal-prote...

After visual and optical testing (VT), the next method of nondestructive testing (NDT) most commonly employed in industry is radiographic testing. Also simply referred to as radiography, it is perhaps the most versatile of the nondestructive testing methods.[1] The basic radiographic process in use today is in large part still the same as it was when it was introduced in the late 1800s. Radiogr...

Arginase (L-Arg amidinohydrolase, EC 3.5.3.1) catalyzes the hydrolysis of L-Arg to urea and L-Orn. Orn is a precursor of Pro and polyamines and urea N is recycled by urease-catalyzed hydrolysis to ammonia (Polacco and Holland, 1993). Many plant species store much seed protein N in Arg (VanEtten et al., 1963), significant quantities of which are released and catabolized during germination (Polac...

<span style="color: #000000; font-family: Tahoma, sans-serif; font-size: 13px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: auto; text-align: -webkit-left; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-stroke-width: 0px; display: inline !important; float: none; ba...

Conventional radiography has been for decades the standard method of evaluation for cervical spine trauma patients. However, currently available helical multidetector CT scanners allow multiplanar reconstruction of images, leading to increased diagnostic accuracy. The purpose of this study was to determine the relative benefit/risk ratio between cervical spine CT and cervical spine radiography ...

A new auto-tuning approach for centralized MIMO PID controllers and unknown process models is presented. Classical multivariable PID controller tuning methods are combined with iterative feedback tuning (IFT) to develop an auto-tuning method with a bounded number of tuning parameters. The method is demonstrated and validated with a steam generator example. Very good simulation results are obtai...