Clinical manifestations of leishmaniasis are diverse and related to the infecting species, its relationship with the environment and the host immune response. A case of late Andean cutaneous leishmaniasis with extensive manifestation is presented. The case was confirmed through microbiological and immunological studies; identification was performed by cytochrome b gene sequencing and the specie...

Giant cell arteritis (GCA) is the most common vasculitis in Western countries in individuals over the age of 50. The diagnosis is relatively straightforward when typical features, such as headache, jaw claudication or other ischemic complications are present. Although atypical presentations of GCA have been described, herein we report for first time low back pain as the presenting manifestation...

Intraglomerular metastasis is a rare manifestation of disseminated malignancies. We present here a case of intraglomerular metastatic carcinoma diagnosed as an incidental finding on a kidney biopsy in a 62-year-old male presenting with acute renal failure and metastatic penile squamous cell carcinoma. A proliferative lesion composed of highly atypical epithelial cells was found within a capilla...

We present the case of a 73-year old patient suffering from chronic flexor tendon synovitis of the wrist with carpal tunnel syndrome. He underwent synovectomy and median nerve release. Primary bacteriology was negative. Histology of the excised synovia revelead non-caseating granuloma as typical for sarcoidosis. Further screening for sarcoidosis was negative. Culture of a sample harvested from ...

Atypical hemolytic uremic syndrome (aHUS) is a rare disease caused by chronic, uncontrolled activation of the alternative complement pathway, leading to thrombotic microangiopathy. Renal impairment and progression to end-stage renal disease are common in untreated patients with aHUS, and extrarenal manifestations are being increasingly characterized in the literature. Ocular involvement remains...

An-80-year-old woman treated with allopurinol showed atypical target lesions with blister and erosions, which rapidly extended over the trunk and limb. She was diagnosed as Toxic Epidermal Necrolysis (TEN). Despite the treatment with pulsed corticosteroids and i.v. immunoglobulins, the skin lesions rapidly extended over the entire body. Strikingly, the progression of blistering with stopped by ...

Pityriasis rubra pilaris (PRP) is a rare papulosquamous dermatosis characterized by keratotic follicular papules, erythematous scaling, pahnoplantar keratoderma and a variable degree of erythroderma. Type I PRP, the most common adult form, has a typical clinical manifestation, and remission in these patients can be achieved within 3 years. However, the rare type II PRP presents atypical feature...

Parinaud oculoglandular syndrome (POGS) is an ocular granulomatous inflammatory condition characterized by unilateral follicular bulbar or palpebral conjunctivitis. Although POGS often presents as an atypical manifestation of cat scratch disease (CSD), other infectious and autoimmune etiologies have been described. Due to the rare nature of this ocular syndrome and scarcity of literature on thi...

INTRODUCTION The incidence of cutaneous metastasis in patients with cancer is estimated to be 0.6% to 10.4%. In women, breast cancer is the most frequent primary malignancy metastasizing to the skin. A large study reported that cutaneous metastasis occurs in 23.9% of patients with breast carcinoma. Different patterns of cutaneous breast carcinoma metastasis have been described, including nodula...

Rosai-Dorfman disease is a benign, self-limited, idiopathic proliferative histiocytic disorder. It was first described in 1969 by Rosai and Dorfman. In its typical form the disease is characterized by extensive cervical lymphadenopathy associated with fever, polyclonal gammopathy and leukocytosis with neutrophilia. The skin is the most common site affected. Extranodal manifestations have been r...