There is a need for treatment interventions to address the high prevalence of disordered eating throughout adolescence and early adulthood. We developed an adolescent-specific manualized CBT protocol to treat female adolescents with recurrent binge eating and tested its efficacy in a small, pilot randomized controlled trial. We present lessons learned in recruiting adolescents, a description of...

Non-myeloablative allogeneic peripheral stem cell transplantation (NST) is a novel therapeutic strategy for patients with hematologic malignancies. Whether non-myeloablative transplants are associated with increased risk of cytomegalovirus (CMV) infections is unknown. To clarify this issue, we compared the outcome of CMV infection following 24 allogeneic non-myeloablative peripheral blood stem ...

OBJECTIVE Tinnitus distress can be reduced by means of cognitive-behavior therapy (CBT). To compensate for the shortage of CBT therapists, we aimed, in this study, to investigate the effects of a CBT-based self-help book guided by brief telephone support. METHODS Seventy-two patients were randomized either to a self-help book and seven weekly phone calls or to a wait-list control condition, l...

BACKGROUND While eating disorder not otherwise specified (EDNOS) is the most common eating disorder (ED) diagnosis in routine clinical practice, no specific treatment methods for this diagnosis have yet been developed and studied. Enhanced cognitive behavioral therapy (CBT-E) has been described and put to the test as a transdiagnostic treatment protocol for all EDs, including EDNOS. Initial res...

Background: Dental phobia is a disabling and clinically significant fear that interferes with the dental care necessary for a child’s or adolescent’s well-being. In fact, the definition of oral health in children and adolescents stresses, not only sound and well-functioning dental and oral structures, but also an absence of dental fear and anxiety. Cognitive behavioral therapy (CBT) is an evide...

OBJECTIVE Attention bias modification treatment (ABMT) is a promising novel treatment for anxiety disorders, but clinical trials have focused largely on stand-alone formats among adults. This randomized controlled trial examined the augmenting effects of threat-based ABMT on cognitive behavioral therapy (CBT) in clinically anxious youth. METHOD Sixty-three treatment-seeking children with anxi...

Chronic pain is a complex physiological and psychological phenomenon. Implicit learning mechanisms contribute to the development of chronic pain and to persistent changes in the central nervous system. We hypothesized that these central abnormalities can be remedied with Cognitive Behavioral Therapy (CBT). Specifically, since regions of the anterior Default Mode Network (DMN) are centrally invo...

OBJECTIVE To examine the relative efficacy of intensive versus weekly cognitive-behavioral therapy (CBT) for children and adolescents with obsessive-compulsive disorder (OCD). METHOD Forty children and adolescents with OCD (range 7-17 years) were randomized to receive 14 sessions of weekly or intensive (daily psychotherapy sessions) family-based CBT. Assessments were conducted at three time p...

Book details Riccardo Dalle Grave, Jason Aronson, The Rowman and Littlefield Publishing Group Inc., Maryland, 2013, vii + 341 pp., ISBN: 978-0-7657-0927-1. In the last 10 years, a new form of cognitive behavioural therapy for eating disorders, called Enhanced Cognitive Behavior Therapy (CBT-E) has been developed and tested by Christopher Fairburn and his colleagues at Oxford University. CBT-E d...

OBJECTIVE(S) Fibromyalgia (FM) is a chronic, common pain disorder characterized by hyperalgesia. A key mechanism by which cognitive-behavioral therapy (CBT) fosters improvement in pain outcomes is via reductions in hyperalgesia and pain-related catastrophizing, a dysfunctional set of cognitive-emotional processes. However, the neural underpinnings of these CBT effects are unclear. Our aim was t...