Intraflagellar transport (IFT) depends on two evolutionarily conserved modules, subcomplexes A (IFT-A) and B (IFT-B), to drive ciliary assembly and maintenance. All six IFT-A components and their motor protein, DYNC2H1, have been linked to human skeletal ciliopathies, including asphyxiating thoracic dystrophy (ATD; also known as Jeune syndrome), Sensenbrenner syndrome, and Mainzer-Saldino syndr...

Occupational therapists often prescribe assistive technology devices (ATDs) to assist persons with disabilities in performing daily living tasks. Estimates suggest that although most ATDs are used, a substantial proportion are never used or are discarded shortly after they are obtained. A review of the literature on ATDs was carried out to identify factors that contribute to ATD use and disuse....

The Core Plan Representation (CPR) [Pease and Carrico, 1996] is an effort to develop a plan representation which supports the representation needs of many different planning systems. It is being developed for the DARPA Joint Task Force Advanced Technology Demonstration (JTF ATD) [Hayes-Roth, 1995], [Hayes-Roth Erman, 1994], [Carrico, 1996]. The goal of this effort is to leverage common function...

Use of insulin in the treatment of type 2 diabetics may vary among different countries from 5% to 50%. The validity of this evaluation may depend on the diabetes type classification of adult insulin-treated patients (ITP). An attempt at such evaluation was made by using data of the Ukrainian Diabetes Mellitus Register (102,580 ITP aged ≥30). ITP were stratified into subgroups according to age a...

Agranulocytosis is a rare and serious adverse effect of antithyroid drugs (ATD), in particular methimazole (MMI), and usually develops within 3 months following the start of uninterrupted ATD treatment. Agranulocytosis may also develop for the first time following interruption and subsequent resumption of the same ATD treatment. In this case report, a 27-year-old female, who was treated for thy...

This paper describes the outcome research project – Automatic Team Detector (ATD) system that has been carried out as a result of implementing the semantic web technology in issue tracking systems (ITSs) to enhance their functionality, performance and qualification. An automatic team detector (ATD) semantic web based application is developed to automatically assign without any human support the...

A semiautomated three-compartment box (3CB) for studying partner preference behavior of rats is described. This apparatus automatically records the rat's time spent in each compartment, as well as the locomotor activity (i.e., the number of visits an animal pays to each compartment). Software was developed for calculating partner preference scores. Behavioral testing in the semiautomated 3CB, w...

OBJECTIVES The goal of this study was to assess the risk associated with double antiplatelet therapy (DAT) discontinuation, and specifically, temporary discontinuation, during the first year after drug-eluting stent (DES) implantation. BACKGROUND Doubts remain about the risk of temporary DAT discontinuation within 1 year after DES implantation. METHODS A total of 1,622 consecutive patients ...

OBJECTIVE There are scarce reports regarding the prognosis of a second course of antithyroid drug (ATD) therapy on recurrent Graves' disease (GD). The aim of this study was to assess the long-term remission rate after a second ATD therapy and verify significant clinical predictors of a remission. DESIGN A prospective randomized clinical trial with long-term follow-up was conducted to evaluate...

Testosterone (T) regulates avian behaviors such as song and aggression during the breeding season. However, the role of T in year-round territorial birds is still enigmatic, especially in tropical birds. Spotted antbirds (Hylophylax n. naevioides) defend territories in the Panamanian rainforest year-round but have low plasma T levels (0.1-0.2 ng/ml), except during brief periods of social challe...