To assess the prevalence of skin test sensitivity among asthmatic patients in Malaysia, skin prick tests for allergy in 134 adult asthmatic patients and 120 control subjects were done. 90% of asthmatic patients had positive skin test to at least one allergens as compared to 78% of the controls. House dust mite was the most frequent allergen to which the subjects had positive reactions. Sixty-fo...

We wanted to determine whether the airway response to inhaled leukotriene C4 (LTC4) is similar to inhaled leukotriene E4 (LTE4) in aspirin-sensitive asthma and, therefore, determined airway responsiveness to histamine, LTC4 and LTE4 in seven aspirin-sensitive subjects and 13 control asthmatic subjects, who were tolerant of aspirin. The concentration of inhaled lysine-aspirin which produced a 15...

This study describes a method of quantitatively characterizing cough sounds using digital signal processing techniques. Differences between asthmatic and non-asthmatic cough sounds are presented. Coughs from 12 asthmatic and 5 non-asthmatic subjects were analysed. Cough sounds and flows were digitized, at a sampling rate of 5 kHz, before and after a free-running exercise test. Individual coughs...

BACKGROUND Excess body mass increases the risk of development of asthmatic symptoms and their severity and decreases the treatment effectiveness. One of the hypotheses explaining the link between the two diseases concerns the adipokines, hormones produced by adipose tissue with a proinflammatory character. The aim of this study was to compare the levels of the adipokines (leptin and resistin) b...

Appreciable numbers of aspirin-sensitive asthmatic patients have chronic steroid-dependent severe asthmatic symptoms. We report four cases of aspirin-sensitive asthmatics who had mild to severe asthmatic symptoms, whose methacholine PC20 level ranged from 0.6 to 22 mg/ml at the first visit. The aspirin sensitivity was confirmed by lysine-aspirin bronchoprovocation. After anti-asthmatic medicati...

dietary fatty acids play a critical role in modulation of airway inflammation in asthma. this study was conducted to compare dietary intakes of essential fatty acids and serum levels of inflammatory factors in asthmatic and healthy adults, and to examine the potential relationship between inflammatory markers and dietary fatty acids. in this case-control study, 47 asthmatic patients (26 males a...

asthma and  gastroesophageal reflux disease (gerd)  are two  common  problems  in pregnancy and they affect pregnancy in several ways. in this study, we aimed to evaluate gerd and asthma in pregnant women who referred for prenatal care visits. one-hundred  and seventy three  pregnant  women with a complaint of  dyspnea were included in the study. a questionnaire was filled and lung function tes...

BACKGROUND Respiratory viral infections can induce different cytokine/chemokine profiles in lung tissues and have a significant influence on patients with asthma. There is little information about the systemic cytokine status in viral respiratory-infected asthmatic patients compared with non-asthmatic patients. OBJECTIVES The aim of this study was to determine changes in circulating cytokines...

Abstract Between March and April 2020, Cyprus Greece health authorities enforced three escalated levels of public interventions to control the COVID-19 pandemic. We quantified compliance 108 asthmatic schoolchildren (53 from Cyprus, 55 Greece, mean age 9.7 years) both countries intervention levels, using wearable sensors continuously track personal location physical activity. Changes in ‘fracti...

Earlier reports from our laboratory established the acetyl transferase function of calreticulin (CRT), enabling CRT to transfer acetyl groups from the acetoxy groups of polyphenolic acetates (PAs) to certain receptor proteins. We have in this paper documented the ability of CRT to catalyze the possible transfer of acetyl moiety from 7-acetamido-4methylcoumarin (7-N-AMC) to the proteins, glutath...