general toxicity, antiproliferative, antibacterial and antioxidant activities of caulerpa peltata j.v.lamouroux (caulerpaceae) collected from oman sea were investigated. dried, ground alga was soxhlet-extracted with hexane, dichloromethane and methanol successively. the methanol extract was subjected to vacuum liquid chromatography (vlc) fractionation on silica gel using a step gradient of diff...

Due to its excellent physicochemical properties, cerium oxide (CeO2) has attracted much attention in recent years. CeO2 nanomaterials (nanoceria) are widely being used, which resulted them getting released the environment, and exposure humans (mostly via inhalation) is a major concern. In present study, nanoparticles were synthesized by hydroxide-mediated method further characterized Scanning E...

Abstract This work evaluates the in vitro antioxidant and antidiabetic activities of two metformin hydrochloride-based Schiff bases. Moreover, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was used to examine cytotoxic effects HL1 HL2 on A549 lung cancer cell line. The bases that have been previously synthesized by using effective, green techniques, namely stirring m...

A study was undertaken to compare the proliferative index of macroschizont-infected lymphoblastoid cells of two Indian strains [Izatnagar (IZT) and Parbhani (PBN)] of Theileria annulata by an in vitro MTT [3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide], colorimetric assay. Culture conditions were standardized to define the optimal cell concentration in 96-well microculture plat...

The cyclooxygenase-2 (COX-2) enzyme binds to arachidonic acid resulting in the release of metabolites that induce pain and inflammatory responses. Recent studies have shown that strong COX-2 expression is highly correlated with increased tumor risk. Therefore, the development of potent COX-2 inhibitors to relieve pain and treat cancers requires further investigation. We used virtual screening t...

BACKGROUND The filarial parasites of major importance in humans contain the symbiotic bacterium Wolbachia and recent studies have shown that targeting of these bacteria with antibiotics results in a reduction in worm viability, development, embryogenesis, and survival. Doxycycline has been effective in human trials, but there is a need to develop drugs that can be given for shorter periods and ...

objective: envenomation by heamotoxic snakes constituted a critical health occurrence in the world. bleeding is the most sever consequence following snake bite with viperid and crothalid snakes. it is believed that the degradation of vascular membrane caused hemorrhage; in contrast, some suggested that direct cytotoxicity has role in endothelial cell disturbances. this study was to evaluate the...

Background and objectives: Juniperus excelsa is a flowering plant that has been applied as traditional medicine for treatment of various disorders such as dysmenorrhea, bronchitis and colds, jaundice and tuberculosis. The aims of the present study were analyzing J. excelsa essential oil and investigation of its cytotoxic activity on three breast cancer cell li...

Introduction: Fluoroquinolones are potent inhibitors of bacterial topoisomerase II. They can also inhibit eukaryotic topoisomerase, and may confer antitumoral properties. Method: In this study the antitumoral activity of a new series of N-substituted piperazinylfluoroquinolones against a panel of human tumor cell lines was determined by MTT assays. Results: Among the tested compounds N-[2- (5-b...