PURPOSE Cerebral ischemic lesions are frequently observed after carotid artery stenting (CAS), and anti-platelet agents are used to prevent stent thrombosis and peri-procedural complications. However, despite the premedication, cerebral ischemic lesions are observed, suggesting that they may rather be related to anti-platelet resistance. We, therefore, investigated the effects of anti-platelet ...

The article is focused on the issues of poor patient adherence to medication treatments, including antiplatelet drugs, its reasons, and solutions for overcoming compliance barriers. As today, treatment remains low leading a higher risk cardiovascular complications. Poor acetylsalicylic acid (ASA) mainly linked relatively frequent development gastrointestinal side effects. this problem include u...

BACKGROUND We evaluated the sensitivity, precision, and concordance of 4 assays designed to detect aspirin responsiveness or resistance. METHODS Twenty-nine healthy laboratory volunteers took 80 mg aspirin for 7 days, and a subset of volunteers took 325 mg aspirin for an additional 7 days. We measured platelet function by light transmission aggregometry with arachidonic acid, PFA-100, and Ver...

The term aspirin resistance has been used to describe the occurrence of cardiovascular events despite regular aspirin intake at recommended doses.1 In this context, such treatment failures resemble those with any drugs, including statins, -blockers, and ACE inhibitors.2,3 In secondary prevention, the clinical effectiveness of aspirin has been clearly demonstrated and is comparable to that of th...

The main pharmacological aspects of pharmacodynamics (PD) and pharmacokinetics (PK) of aspirin as antiplatelet agent were unravelled between the late sixties and the eighties, and low-dose aspirin given once daily has been shown to be a mainstay in the current treatment and prevention of cardiovascular disorders. Nevertheless, several PD and PK aspects of aspirin in selected clinical conditions...

Hepatocellular carcinoma (HCC) is the sixth and fourth common cancer in worldwide Egypt. Transarterial chemoembolization (TACE) standard treatment for unresectable HCC. Recent studies showed that TACE refractoriness impairs survival of HCC patients. Various strategies under investigation aim to improve outcome TACE, Aspirin demonstrated chemopreventive, antithrombotic anti-inflammatory properti...

BACKGROUND Despite the proven benefits of clopidogrel combined aspirin therapy for coronary artery disease (CAD), CAD patients with metabolic syndrome (MS) still tend to have coronary thrombotic events. We aimed to investigate the influence of metabolic risk factors on the efficacy of clopidogrel treatment in patients with CAD undergoing percutaneous coronary intervention (PCI). METHODS Cohor...

We read with interest the review paper on aspirin and clopidogrel resistance by Wang et al.1 We agree that it is an emerging entity with important clinical implications. Nevertheless, we were surprised that very little emphasis was put on the antiplatelet agent resistance of diabetic patients. Only one short sentence mentioned that hyperglycaemia may decrease the effectiveness of antiplatelet t...

Aspirin is a prototypic cyclooxygenase inhibitor with a variety of beneficial effects on human health. It prevents age-related diseases and delays the aging process. Previous research has shown that aspirin might act through a dietary restriction-like mechanism to extend lifespan. To explore the mechanism of action of aspirin on aging, we determined the whole-genome expression profile of Caenor...

grel resistance: role of body mass and concomitant medications. Int J Cardiol 2007; 120:188–192. 84. Tamminen M, Lassila R, Westerbacka J, Vehkavaara S, Yki-Jarvinen H. Obesity is associated with impaired platelet-inhibitory effect of acetylsalicylic acid in nondiabetic subjects. Int J Obes Relat Metab Disord 2003;27:907–911. 85. Markuszewski L, Rosiak M, Golanski J, Rysz J, Spychalska M, Watal...