background: the most devastating manifestations of diabetes mellitus are vascular complications. although there are many factors involved in the pathogenesis of diabetic vasculopathy, many studies suggest a role for glucose–induced oxidative stress. studies in animal models, have demonstrated that the administration of antioxidants restores normal endothelial functions. the study was designed t...

OBJECTIVES To study effects of hypochlorous acid (HOCl) on equine colonic mucosa in vitro, and determine whether addition of ascorbic acid protects against the effects. ANIMALS 6 healthy horses and ponies. PROCEDURE Short-circuit current was measured in mucosa mounted in Ussing chambers. Incubation conditions were: control (no additions); 5 mM HOCl; 1 mM HOCl; same and 5 mM ascorbic acid; 3...

AIM Glioblastoma (GBM) is one of the lethal central nervous system tumors. One of the widely used chemical agents for the treatment of glioblastoma is temozolomide. It is an orally administered, deoxyribonucleic acid (DNA) alkylating agent. DNA alkylation triggers the death of tumor cells. However, some tumor cells are able to repair this type of DNA damage and thus lower the therapeutic effect...

Blood levels of ascorbic acid, vitamin A, folic acid, and amino acids were studied in patients at the South Texas Comprehensive Hemophilia Center, San Antonio, TX. The mean plasma ascorbic acid level in hemophiliacs was significantly lower than controls (p less than 0.0001). This was observed despite a dietary ascorbic acid intake in excess of 66% of the Recommended Dietary Allowances (RDA). Ho...

The inhibiting effect of ascorbic acid, citric acid and sodium chloride on Polyphenoloxidase (PPO) of Golden Delicious apple cubes was studied. Dipping in ascorbic acid (0.2-10 g/L range) and in NaCl (0.2-1 g/L range) solutions for 5 min increases the PPO activiry. Citric acid solutions (0.2-10 g / L range) have little or no inhibition of PPO. A 90-100% PPO inhibition was obtained with a 5 min ...

Efficiency was examined of microencapsulating L-ascorbic acid by polyglycerol monostearate (PGMS), and changes in the chemical and sensorial aspects of L-ascorbic acid and/or iron-fortified milk during storage were evaluated. The selected core materials were ferric ammonium sulfate and L-ascorbic acid. The highest efficiency (94.2%) of microencapsulation was found with the ratio of 5:1 as the c...

A number of investigations (2, 3, 6, 7, 10) within the past 10 years has demonstrated the significance of determining ascorbic acid in the whole blood or white blood cells in assessing the vitamin C nutriture of individuals. These studies have shown (a) that the blood cells may contain ascorbic acid when there is no vitamin in the serum (2, 3), (b) that scurvy does not appear until the cellular...

Ascorbic acid and nitric oxide are known to play important roles in epilepsy. The aim of present study was to identify the involvement of nitric oxide (NO) in the anticonvulsant effects of ascorbic acid on penicillin-induced epileptiform activity in rats. Intracortical injection of penicillin (500, International Units (IU)) into the left sensorimotor cortex induced epileptiform activity within ...

Previous studies showed that the intact carbon chain of glucose can serve as a precursor for the synthesis of ascorbic acid in the rat (l-3). Evidence for such a precursor relationship came from experiments in which glucose tracers labeled in carbon 1 and carbon 6 were administered to rats, and the L-ascorbic acid isolated from urine was labeled predominantly in carbon 6 and carbon 1, respectiv...

The biosynthesis of i-ascorbic acid (vitamin C) is not well understood in plants. The ozone-sensitive Arabidopsis thaliana mutant vifamin cl (vfcl; formerly known as sozl) is deficient in ascorbic acid, accumulating approximately 30% of wild-type levels. This deficiency could result from elevated catabolism or decreased biosynthesis. No differences that could account for the deficiency were fou...