نتایج جستجو برای: artesunate
تعداد نتایج: 1720 فیلتر نتایج به سال:
In contrast, the treatment of severe/complicated childhood malaria appears to be evolving. The 2005 IAP Guideline followed the National Malaria Programme and recommended quinine, suggesting artesunate/artemether as less preferred alternatives(3). In 2008, it was modified as quinine with tetracycline/doxycycline/clindamycin(4) in line with the WHO 2006 statement. The National Guideline 2009(2) s...
A dose regimen of artesunate and amodiaquine based on arm span- or age range (DRAAAS), derived from a study of 1674 children, was compared with standard dose regimen of the same drugs calculated according to body weight (SDRAA) in 68 malarious children. Children on DRAAAS received 0.8-1.0 of artesunate/kg and 0.9-1.2 times amodiaquine/kg compared with those receiving SDRAA. Parasite and fever c...
7. Jones KL, Donegan S, Lalloo DG. Artesunate versus quinine for treating severe malaria. Cochrane Database Syst Rev. 2007;(4):CD005967. 8. World Health Organization. Guidelines for the treatment of malaria. 2006 [cited 2008 Sep 11]. Available from http://www. who.int/malaria/docs/TreatmentGuidelines2006.pdf 9. Jelinek T. Intravenous artesunate recommended for patients with severe malaria: posi...
Abstract One of the hallmarks malaria infection is oxidative stress. This study was aimed at investigating potential effects coadministering a therapeutic dose artesunate–amodiaquine (AS/AQ) with Vitamin C (Vit C) orally on some biochemical parameters and antioxidant enzymes gene expression in bone marrow cells Plasmodium berghei -infected mice. Thirty male Swiss albino mice were divided into f...
The global need for new antimalarial drugs and new combinations is enormous and urgent, but their successful delivery needs resilience to overcome the barriers imposed by expensive and lengthy clinical development plans. Attention is often directed to areas such as southeast Asia, where some antimalarial combinations are failing but transmission intensities are much lower than in sub-Saharan Af...
The histological effect of oral administration of artesunate, commonly used for the treatment of Malaria on the medial geniculate body (MGB) of adult wistar rat was carefully studied. The rats of both sexes (n=24), average weight of 210g were randomly assigned into three treatment (n=18) and control (n6) groups. The rats in the treatment group 'A' received 4mg/kg body weight of artesunate base ...
In addition to their well-known anti-malarial activity, artemisinin and its derivatives (1,2,4-trioxanes) possess potent activity against tumor cells in the nano- to micromolar range. Candidate genes that may contribute to the sensitivity and resistance of tumor cells to artemisinins were identified by pharmacogenomic and molecular pharmacological approaches. Target validation was performed usi...
BACKGROUND Artemisinin combination treatments (ACT) are recommended as first line treatment for falciparum malaria throughout the malaria affected world. We reviewed the efficacy of a 3-day regimen of mefloquine and artesunate regimen (MAS(3)), over a 13 year period of continuous deployment as first-line treatment in camps for displaced persons and in clinics for migrant population along the Th...
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