DUCHENE MUSCULAR DYSTROPHY (DMD) is a severe inherited disease of striated muscle caused by a mutation of the dytrophin gene (7). Dystrophin is part of a large complex that forms a transmembrane bridge between nonsarcomeric actin on the intracellular end and the extracellular matrix on the other. Disruption of this complex is thought to result in plasma membrane instability and defective cellul...

Women are eight times less likely to develop myocardial infarction than men are; nonetheless, when myocardial ischemic disease is present, it has a worse evolution . No explanations for this fact are available, although speculations exist about the inadequate manner of diagnosis. It is worth emphasizing that in studies about coronary disease, women are either a minority or excluded from the stu...

DUCHENE MUSCULAR DYSTROPHY (DMD) is a severe inherited disease of striated muscle caused by a mutation of the dytrophin gene (7). Dystrophin is part of a large complex that forms a transmembrane bridge between nonsarcomeric actin on the intracellular end and the extracellular matrix on the other. Disruption of this complex is thought to result in plasma membrane instability and defective cellul...

During the past 12 months chloroquine and hydroxychloroquine have been touted as miracle cures for COVID‐19 introduced into treatment protocols in Asia, Africa, North South America (see Figure 1). This has led to massive increases demand such that patients with rheumatoid arthritis lupus deprived of effective treatments. A Cochrane Review by Bhagteshwar Singh colleagues definitively concludes n...

Since the first report of an association between cardiac troponin (cTn) and adverse outcome in hypertrophic cardiomyopathy (HD), there is a paucity confirmative data. We performed prospective, prespecified 5-year follow-up cohort study 135 HC patients who participated national multicenter project underwent clinical evaluation, MRI (cine, LGE T2-weighted imaging) biomarker assessment (high-sensi...

____________ _ A 27 -year-old male patient presented for elective arrythmia surgery. Due to the nature of the surgical procedure, i.e. normothermic bypass, light anaesthetic, dislocation of the heart, etc., the physical size of this patient was of concern. The patient was 183 em tall and weighed 141 kg. The calculated body surface area was 2.68 M2 and the calculated flow was 6.7 LPM. Because of...