Direct oral anticoagulants (DOACs) have shifted the landscape of anticoagulation over past decade, becoming a frequently used pharmaceutical agent. The increased use DOACs for long-term has led to rise in reported anticoagulant-related adverse reactions, such as nephropathy (ARN). occurrence ARN is well with warfarin; however, there are few cases DOAC use. We report case an elderly man coronary...

The androgen receptor (AR) surface-directed antagonist MJC13 inhibits AR function and proliferation of prostate cancer (PC) cells. These effects are related to arrest of an AR/chaperone complex in the cytoplasm. Here, we compared MJC13 and classic AR antagonists such as flutamide and bicalutamide. Microarray analysis and confirmatory qRT-PCR reveals that MJC13 and flutamide inhibit dihydrotesto...

El ARN de interferencia (ARNi) es un mecanismo evolutivamente conservado en la mayoría las células eucariotas que permite silenciar genes mediante degradación mensajero (ARNm) y supresión síntesis proteínas. En plantas, moléculas ARNi están involucradas mecanismos defensa contra patógenos transposones, respuesta adaptativa al estrés, expresión relacionados con su crecimiento. se considera una h...

The association between the entomophagous Lepidoptera Laetilia coccidivora (Comstock, 1879) is recorded for first time with species of Coccoidea Coccus pseudomagnoliarum (Kuwana, 1914). This phytophagous insect also represents record Mexico. material was obtained from municipality Cortazar, Guanajuato, host plant, Acacia farmesiana (L.) Willd. & Arn., a new as scale insect. voracity larvae ...

1215 Calcium Channels: Critical Targets of Toxicants and Diseases Gerald Audesirk,1 David Armstrong,2 Arn M.J.M. van den Maagdenberg,3 William Atchison,4 Timothy Shafer,5 and Colin Fletcher 6 1Biology Department, University of Colorado at Denver, Denver, Colorado, USA; 2Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina...