نتایج جستجو برای: arg72pro
تعداد نتایج: 196 فیلتر نتایج به سال:
INTRODUCTION Obtaining an adequate number of high-quality oocytes is a major challenge in controlled ovarian hyperstimulation (COH). To date, a range of hormonal and clinical parameters have been used to optimize COH but none have significant predictive value. This variability could be due to the genetic predispositions of single-nucleotide polymorphisms (SNPs). Here, we assessed the individual...
BACKGROUND A multiple pregnancy is now considered to be the most common adverse outcome associated with in vitro fertilization (IVF). As a consequence, the identification of women with the best chances of embryo implantation is a challenge in IVF program, in which the objective is to offer elective single-embryo transfer (eSET) without decreasing the pregnancy rate. To date, a range of hormonal...
PURPOSE To provide new insights into the genetic basis of normal tissue radiosensitivity, we evaluated the association between eight polymorphic variants located in six genes related to DNA repair mechanisms, oxidative stress, and fibroblast proliferation (XRCC1 Arg399Gln, XRCC1 Arg194Trp, TP53 Arg72Pro, GSTP1 Ile105Val, GSTA1 C-69T, eNOS G894T, TGFβ1 C-509T, and TGFβ1 T869C) and the risk of su...
s. BMCMed Inform Decis Mak. 2007;7:17.23. Hainaut P, Hernandez T, Robinson A, et al. IARC database ofp53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools.Nucleic Acids Res. 1998;26(1):205–213. 24. Hainaut P, Soussi T, Shomer B, et al. Database of p53 genesomatic mutations in human tumors and cell lines: updatedco...
Oral squamous cell carcinoma (OSCC) is one of the most common malignant neoplasms worldwide. Oral cancer forms a large part of the cancer load in the part of India [1]. Smoking, alcohol, drinking, viral infection and genetic factors are the major risk factors involved in the etiology of oral squamous cell carcinoma. Some molecular studies have provided some clues to the molecular mechanisms und...
Results of studies performed in our center point at DNA changes of many cancer (mostly moderate) susceptibility genes. Association of “weak” mutations and polymorphism of many genes and additional influence of environmental factors can significantly increase the risk of cancer development. The preliminary studies performed in our department indicate, that increased risk of gastric cancer may be...
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