The purpose of this study was to investigate whether juvenile sexual offenders use substances and engage in substance related criminality or if other forms of criminality (e.g. sexual or nonsexual crime) are associated with substance use. Three related quantitative articles were written to execute this project. The first article explored the prevalence of substance use and related crime among s...

Annamycin (Ann) is a new lipophilic anthracycline antibiotic with a marked ability to circumvent typical multidrug resistance both in vitro and in vivo. Because of its high affinity for lipid membranes and very low solubility in water, Ann has been prepared in a submicron liposome formulation (L-Ann) that is currently being investigated in a Phase I clinical study. We studied the preclinical to...

In this paper we consider the problem of comparison two strictly stationary processes. The novelty our approach is that all their d-dimensional joint distributions, for $$d\geqslant 1$$ . Our procedure consists in expanding densities a multivariate orthogonal basis and comparing k first coefficients. dimension d to number coefficients compare view performing test can growth with sample size are...

The lipophilic anthracycline antibiotic annamycin (Ann) was entrapped in liposomes of different size [median diameter: 1.64 microns, multilamellar liposomal Ann (L-Ann); 0.030 micron, small unilamellar Ann (S-Ann)] with > 90% entrapment efficiency and tested in vitro against four pairs of sensitive and multidrug-resistant (MDR) tumor cell lines and in vivo by the i.v. route in five tumor models...

Departments of Internal Medicine and Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, USA Ann Arbor Veterans Affairs Healthcare System, and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States Ann Arbor Veterans Affairs Healthcare System, Ann Arbor, Michigan, USA Departments of Internal Medicine and Learning Health Science...

Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA Statistics Online Computational Resource (SOCR), University of Michigan School of Nursing, Ann Arbor, MI, USA Department of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI, USA Michigan Institute for Data Science (MIDAS), University of Michigan, Ann Arbor, ...