نتایج جستجو برای: ar
تعداد نتایج: 61795 فیلتر نتایج به سال:
Molecularly targeted therapies for advanced prostate cancer include castration modalities that suppress ligand-dependent transcriptional activity of the androgen receptor (AR). However, persistent AR signalling undermines therapeutic efficacy and promotes progression to lethal castration-resistant prostate cancer (CRPC), even when patients are treated with potent second-generation AR-targeted t...
BACKGROUND Increased prevalence of attention-deficit/hyperactivity disorder (ADHD) in children with allergic rhinitis (AR) has been reported. Our previous study showed that children with untreated AR had higher ADHD scores than did the controls. OBJECTIVE This prospective follow-up study aimed to investigate whether elevated ADHD scores in children with AR could be decreased by AR treatment. ...
PURPOSE The α₁A-adrenoceptor (α₁A-AR) subtype was suggested to mediate contraction and trophic effects in the iris dilator muscle, and thus its pharmacological blockade may be involved in intraoperative floppy iris syndrome. We tested the hypothesis that the α₁A-AR mediates pupil dilation and trophic effects in the mouse iris. METHODS The α₁-AR subtype mRNA expression was quantified in iris t...
Augmented Reality (AR) has been acclaimed as one of the promising technologies for advancing future UbiComp (Ubiquitous Computing) environments. Despite a myriad of AR applications and its influence on the human–computer interaction field, end products that integrate AR are less commonplace than expected. This is due to a lack of being able to forecast in which direction mainstream standardizat...
با توجه به نقش بازیابی در محاسبه ارزش اقتصادی بلوک کانسنگ و تأثیر مقدار این ارزش بر محاسبات طراحی و برنامه‌ریزی تولید معدن، تعیین بازیابی فلز از بلوک کانسنگ ارسالی به کارخانه فرآوری، از اهمیت بالایی برخوردار است. هدف از این پژوهش، بررسی قابلیت برآورد بازیابی بلوک کانسنگ به<span lang="AR-SA" dir="R...
در این پژوهش اثر پنج پارامتر موثر در ترمودسیفونهای دو فازی بسته ازجمله نسبت پر شدن fr زاویه شیب نسبت منظری ar حرارت ورودی q دبی آب خنک کنند m بر روی خصوصیات حرارتی از جمله ضریب انتقال تحرارت جابجایی در تبخیر کننده و چگالنده و نیز راندمان ترموسیفون مورد بررسی قرار گرفته است. سیال عامل مورد استفاده در لوله متانول بوده و نتایج نشان می دهد که مقدار h با افزایش نسبت پر شدن افزایش و برای 7/17 =ar و ب...
Posttranslational protein modifications can play a major role in disease pathogenesis; phosphorylation, sumoylation, and acetylation modulate the toxicity of a variety of proteotoxic proteins. The androgen receptor (AR) is substantially modified, in response to hormone binding, by phosphorylation, sumoylation, and acetylation; these modifications might thus contribute to DHT-dependent polygluta...
The androgen receptor (AR) is a major therapeutic target in prostate cancer pharmacology. Progression of prostate cancer has been linked to elevated expression of AR in malignant tissue, suggesting that AR plays a central role in prostate cancer cell biology. Potent therapeutic agents can be precisely crafted to specifically target AR, potentially averting systemic toxicities associated with no...
Advanced hormone-independent prostate cancer is characterized by a significant loss of androgen receptor (AR) expression in 20–30% of the tumors. The transcriptional block underlying this phenomenon is not known, but we have proposed that methylation of CpG sites in the AR promoter may reversibly inactivate transcription of the AR (D. F. Jarrard et al., Cancer Res., 58: 5310–5314, 1998). In thi...
The androgen receptor (AR) gene is transcriptionally regulated by AR (autoregulation); however, the androgen response elements (AREs) required for this process have not been found in the AR promoter or in the 5'-flanking region. We previously showed that the AR cDNA contains AREs involved in AR mRNA autoregulation and that auto(up)regulation is reproduced in PC3 cells (a human prostate cancer c...
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