Thromb Haemost 2008; 100: 9–10 Downey et al. published a paper in 1997 entitled ‘Novel and diagnostically applicable information from optical waveform analysis of blood coagulation in disseminated intravascular coagulation’ (1). Using a new automated coagulation analyzer, the MDA-180, the authors observed that during measurement of the aPTT, some samples became turbid immediately after addition...

Unfractionated heparin (UFH) remains an important therapeutic modality for anticoagulation in children. Its short half-life and easy reversibility with protamine sulfate make it an attractive option in critically ill children. Although initially described as a screening tool for hemophilia, the aPTT is a global hemostatic assay that reflects the integrity of the intrinsic and common pathways of...

COVID-19患者では，凝固異常が合併しやすいことが知られている．私たちは，ACL-TOP 700 hemostasis testing systemにて，APTT凝固波形解析をしたところ，COVID-19患者では，高率に凝固波形パターン異常がみられることを経験した．その後の報告をみると，当該測定系以外の測定系では，このような波形パターン異常は報告されておらず，測定系特異的な現象と考えられる．一方で，凝固塊の形成速度，加速度を示す指標は，調べた範囲のすべての測定系で上昇しており，COVID-19での凝固異常をAPTT凝固波形解析は反映していると考えられる．その機序としては，現在のところ特定できていないが，凝固波形パターン異常を示す検体では，特にフィブリノゲンが高値を示していた．その他，ループスアンチコアグラント，VWF/ADAMTS13，血中脂質の変動などが要因として考えられる．一...

abstract background tumor lysis syndrome (tls) is an oncologic emergency that results from massive lysis of malignant cells. the incidence of tls depends on the risk factors, such as baseline hyperuricemia, bulky tumor burden, elevated serum ldh, and elevated wbc. the objectives of the present study were to assess frequency of tumor lysis syndrom in children with all in two methods of induction...

The traditional diagnostic tests for tuberculosis consist of an acid fast stain and a culture test from a sputum sample. With the emergence of drug resistant strains of tuberculosis, nucleic acid amplification has become the diagnostic test of choice. The nucleic acid amplification test consists of four steps: sputum sample collection, lysis of bacilli to release DNA, DNA amplification by PCR a...

BACKGROUND In rodents, Growth Hormone (GH) has been shown to stimulate coagulation parameters, including Prothrombin Time (PT), activated Partial Thromboplastin Time (aPTT) and vitamin K dependent coagulation factors. However, there are no reports on the influence of GH replacement therapy on global coagulation tests in Growth Hormone Deficiency (GHD). OBJECTIVE The aim of this study was to i...

Prothrombinase-induced clotting time (PiCT) determines the anticoagulant effects of heparins, low molecular weight heparins (LMWHs), and direct thrombin inhibitors. At present, this is the only method that measures the effects of all of these inhibitors, in contrast to the prothrombin time, activated partial thromboplastin time (aPTT), Heptest, ecarin clotting time, and the chromogenic assays. ...

Abstract This study is aimed at investigating the relationship between treatment modality, glycemic control and blood homeostasis as represented by prothrombin time (PT) activated thromboplastin (APTT) in T2DM patients. Sixty-four type 2 diabetic patients (40 males 24 females) on metformin or insulin both for not less than six months of ages 20 75 years were selected during their visit to Diabe...