Tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. To date, there is no information on the pharmacokinetics of tacrolimus in Iranian liver transplant recipients. This study was designed to determine pharmacokinetic properties of orally administe...

background: omeprazole is metabolized predominantly by cyp2c19, a polymorphically expressed enzymes that show marked interindividual and interethnic variation. these variations cause a substantial differences that have been reported in the pharmacokinetics of omeprazole. the aim of the present study was to evaluate the pharmacokinetic parameters of omeprazole in a random iranian population. met...

The purpose of this study was to develop a method for directly measuring bone density of femoral neck sections. Three types of density were measured. Real density equals wet weight divided by the actual volume of bone tissue (real volume). Apparent density equals wet weight divided by the total volume occupied by the bone plus the pore spaces (total sample volume). Ash density equals the ash we...

In this work, three different particle sizes: the static radius Rs, hydrodynamic radius Rh and apparent hydrodynamic radius Rh,app obtained using the light scattering technique, are investigated for dilute poly-disperse homogenous spherical particles with a simple assumption that the hydrodynamic radius is in proportion to the static radius, when the Rayleigh-Gans-Debye approximation is valid. ...