نتایج جستجو برای: apoptosis stress

تعداد نتایج: 576780  

2010
Sanjeev Gupta Ayswaria Deepti Shane Deegan Fernanda Lisbona Claudio Hetz Afshin Samali

Endoplasmic reticulum (ER) stress is a feature of secretory cells and of many diseases including cancer, neurodegeneration, and diabetes. Adaptation to ER stress depends on the activation of a signal transduction pathway known as the unfolded protein response (UPR). Enhanced expression of Hsp72 has been shown to reduce tissue injury in response to stress stimuli and improve cell survival in exp...

2015
Jiaojiao Shi Qi Jiang Xiangwei Ding Wenhua Xu Dao W. Wang Minglong Chen

BACKGROUND AND OBJECT Cell apoptosis is a contributing factor in the initiation, progression and relapse of atrial fibrillation (AF), a life-threatening illness accompanied with stroke and heart failure. However, the regulatory cascade of apoptosis is intricate and remains unidentified, especially in the setting of AF. The aim of this study was to explore the roles of endoplasmic reticulum (ER)...

Journal: :Israel Journal of Plant Sciences 2021

Abstract Skin ischemia-reperfusion (I/R) injury is a serious condition that compromises skin flap surgery and leads to organ dysfunction. It arose due restoration of blood supply after prolonged ischemia. The present study was conducted explore the possible protective Isoliquiritigenin (ISL) on in rats. ISL administered rats dose 10 mg/kg, 20 30 mg/kg. effect quantified tissue following I/R var...

Journal: :American journal of physiology. Endocrinology and metabolism 2006
Yuren Wei Dong Wang Farran Topczewski Michael J Pagliassotti

Accumulation of lipids in nonadipose tissues can lead to cell dysfunction and cell death, a phenomenon known as lipotoxicity. However, the signaling pathways and mechanisms linking lipid accumulation to cell death are poorly understood. The present study examined the hypothesis that saturated fatty acids disrupt endoplasmic reticulum (ER) homeostasis and promote apoptosis in liver cells via acc...

Journal: :The Journal of biological chemistry 2012
Carl D Bortner Alyson B Scoltock Maria I Sifre John A Cidlowski

Apoptosis is a stochastic, physiological form of cell death that is characterized by unique morphological and biochemical properties. A defining feature of apoptosis in all cells is the apoptotic volume decrease or AVD, which has been considered a passive component of the cell death process. Most cells have inherent volume regulatory increase (RVI) mechanisms to contest an imposed loss in cell ...

2014
Xiaofei Zhao Xiangguo Liu Ling Su

BACKGROUND Parthenolide (PTL) is a sesquiterpene lactone which can induce apoptosis in cancer cells and eradicate cancer stem cells such as leukemia stem cells, prostate tumor-initiating cells and so on. However, the mechanism remains largely unclear. METHODS Lung cancer cells were treated with parthenolide and the cell lysates were prepared to detect the given proteins by Western Blot analys...

2018
Hongbo Li Yanan Liu Zhengtao Gu Li Li Yunsong Liu Lin Wang Lei Su

Previous studies have demonstratedf that heat stress can induce injury of the central nervous system and lead to neuronal cell apoptosis. However, the molecular mechanisms underlying these cellular changes remain unclear. In the present study, flow cytometry was used to investigate heat-stress-induced apoptosis, and caspase-3 activation was also assessed in neurons. The role of reactive oxygen ...

Journal: :Cancer research 2008
Chen Chen Jiang Keryn Lucas Kelly A Avery-Kiejda Margaret Wade Charles E deBock Rick F Thorne John Allen Peter Hersey Xu Dong Zhang

We have previously shown that most melanoma cell lines are insensitive to endoplasmic reticulum (ER) stress-induced apoptosis, and this involves activation of the mitogen-activated protein/extracellular signal-regulated kinase (MEK)/ERK signaling pathway and expression of the apoptosis repressor with caspase recruitment domain (ARC) protein in the cells. In the present study, we show that up-re...

2008
Penny E. Lovat Marco Corazzari Jane L. Armstrong Shaun Martin Vittoria Pagliarini Anna M. Brown Mauro Piacentini Mark A. Birch-Machin Christopher P.F. Redfern

Exploiting vulnerabilities in the intracellular signaling pathways of tumor cells is a key strategy for the development of new drugs. The activation of cellular stress responses mediated by the endoplasmic reticulum (ER) allows cancer cells to survive outside their normal environment. Many proteins that protect cells against ER stress are active as protein disulfide isomerases (PDI) and the aim...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2000
U Namgung Z Xia

c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein kinase are activated by stress and are implicated in regulation of apoptosis in several tissues. However, their contribution to stress-induced apoptosis in CNS neurons is not well defined. Here we investigated the role of JNK and p38 in cortical neuron apoptosis caused by sodium arsenite treatment. Sodium arsenite is an env...

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