A mathematical model for the transport of hydrophobic organic contaminants in an aquifer under simplistic riverbank filtration conditions is developed. The model considers a situation where contaminants are present together with dissolved organic matter (DOM) and bacteria. The aquifer is conceptualized as a four-phase system: two mobile colloidal phases, an aqueous phase, and a stationary solid...

Pregnant ewes and their fetuses were instrumented between 110 to 120 days of gestation (term, 145 days) for monitoring heart rate, blood pressure, uterine artery blood flow, and fetal intra-abdominal umbilical artery blood flow and arterial blood gases. DOM (2,5-dimethoxy-4methyl-amphetamine) was administered intravenously to the ewe in doses of 1, 2.5, 5, 10, or 20 fig/kg. Maternal administrat...

Parafibromin, a component of the RNA polymerase II-associated PAF1 complex, is a tumor suppressor linked to hyperparathyroidism-jaw tumor syndrome and sporadic parathyroid carcinoma. Parafibromin induces cell cycle arrest by repressing cyclin D1 via an unknown mechanism. Here, we show that parafibromin interacts with the histone methyltransferase, SUV39H1, and functions as a transcriptional rep...

Neuroblastoma is the most common extra cranial solid tumor in childhood and the most frequently diagnosed neoplasm during the infancy. MYCN amplification and overexpression occur in about 25% of total neuroblastoma cases and this percentage increases at 30% in advanced stage neuroblastoma. So far, MYCN expression profile is still one of the most robust and significant prognostic markers for neu...

Transformations of dissolved organic matter (DOM) in boreal lakes lead to large greenhouse gas emissions as well as substantial carbon storage in sediments. Using novel molecular characterization approaches and photochemical degradation experiments we studied how seasonal patterns in water column stratification affected the DOM in a Swedish lake under early spring and summer conditions. Dissolv...

Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) and related drugs have been studied extensively in rodents, although the generality of those findings across species is not known. The goals of this study were to see whether monkeys could discriminate DOM and to characterize the DOM discriminative stimulus by studying a variety of drugs, including those wi...

Methyl-CpG binding protein 2 (MeCP2) is a transcriptional regulator and chromatin-associated structural protein. MeCP2 deregulation results in two neurodevelopmental disorders: dysfunction associated with Rett syndrome, while excess of activity duplication syndrome. an intrinsically disordered (IDP) constituted by six domains variable, small percentage well-defined secondary structure. Two doma...

presentation Puto, L.A., Kitada, S., Krajewska, M., Glinsky, G., Hunter, T., and Reed, J.C. Transcriptional repressor Daxx regulates Dapk1 expression, autophagy, apoptosis, and tumorigenicity of prostate cancer cells. American Association for Cancer Research, Special Conference: Cell Death Mechanisms and Cancer Therapy; February 1-4, 2010; San Diego, California; Abstract # A7.

Prostate cancer is the most frequently diagnosed cancer in men and the second leading cause of male cancer death in the United States. Early detection and improved procedures for surgical intervention and radiation therapy have reduced the fatalities; however, there is no effective cure for men with advanced disease and additional therapy is urgently needed. We have previously shown that MBP-1 ...

This study evaluated the impact of DOM from two biochars (sugar beet tailing and Brazilian pepper) on Cr(VI) reduction and As(III) oxidation in both ice and aqueous phases with a soil DOM as control. Increasing DOM concentration from 3 to 300mgCL(-1) enhanced Cr(VI) reduction from 20% to 100% and As(III) oxidation from 6.2% to 25%; however, Cr(VI) reduction decreased from 80-86% to negligible w...