Apoptotic cell death is a highly regulated process, which plays a crucial role in many biological events. The aim of the present research was to investigate the expression of the apoptosis related genes BCL2 and BAX in Hep-2 and HL60 cells. Apoptosis was induced in these cell lines during treatment with etoposide. The expression levels of BCL2 and BAX genes were measured after 6 h and 12 h of t...

Bronchopulmonary dysplasia (BPD) is one of the main causes chronic lung disease in premature infants. Acute injury following exposure to hyperoxia contributes development BPD preterm The nuclear factor‑erythroid 2‑related factor 2 (Nrf2) signaling pathway an endogenous antioxidant defense mechanism that involved pathogenesis numerous hyperoxia‑induced diseases. In present study, expression Nrf2...

The aim of this study was to explore the pivotal genes or lncRNAs involved in progression atrial fibrillation (AF) -valvular heart disease (VHD). mRNA profiling GSE113013 obtained from Gene Expression Omnibus database. identification differentially expressed (DEGs) and long non-coding RNAs (DElncRNAs) performed. Ontology Kyoto Encyclopedia Genes Genomes pathway enrichment analyses were carried ...

Apoptosis is an integral part of the spermatogenic process, necessary to maintain a proper ratio of Sertoli to germ cell numbers and provide an adequate microenvironment to germ cells. Apoptosis may also represent a protective mechanism mediating the elimination of abnormal germ cells. Extensive apoptosis occurs between the first and second postnatal weeks, at the point when gonocytes, precurso...

Lung cancer is the leading cause of cancer related death and there is no effective treatment to date. Bufalin has been shown effective in inducing apoptosis and DNA damage in lung cancer cells. However, the genetic mechanisms underlying these actions have not been elucidated yet. Cultured NCI-H460 cells were treated with or without 2 μM of bufalin for 24 h. The total RNA was extracted from each...

Introduction: Pain is valuable in diagnosis and also warning of the patients. Many molecular reagents are introduced which are related to pain. In this research, the pain-related genes are screened to identify the critical ones.  Methods: First, the pain-related genes were pulling out from the STRING database, and Cytoscape software was used to make the interactome unit. Then the central genes...

This exploratory biomarker analysis aimed to identify prognostic gene sets in the. T-DM1 and H arms of the phase III KATHERINE study (NCT01772472). RNA sequencing was performed on post-NAT surgical samples. Genes pathways associated with prognosis were identified using DGE, comparing pts invasive disease-free survival (iDFS) events censored at a 3-year cut-off, set enrichment (GSEA), Hallmark, ...

Back ground: Although the cell differentiation is an inseparable part of development in multicellular organisms, the regulating molecular pathway of it still is not fully defined. In the other hand, apoptosis is a fundamental physiological process which plays an essential role in a variety of biological events during development. Moreover, recent studies have found that apoptosis shows several ...

TNF-related apoptosis inducing ligand (TRAIL) is a promising anticancer agent because of its ability to selectively induce apoptosis in cancer cells but not in most normal cells. However, some cancer cells are resistant to TRAIL cytotoxicity thereby limiting its therapeutic efficacy. Using genome-wide mRNA expression profiles from the NCI60 panel and their differential sensitivities to TRAIL-in...