نتایج جستجو برای: apoptosis inflammasomes resveratrol

تعداد نتایج: 164971  

Journal: :Genetics and molecular research : GMR 2016
J P Li Q Ma C M Chen

This study aims to evaluate the cytotoxicity of resveratrol on QGY-7701 cells via a cell viability assay, and determine the cytological alterations and damages that result. Resveratrol was found to inhibit QGY-7701 cell growth and decrease their viability in a remarkably dose-dependent manner. Resveratrol exposure also induced an increase in Caspase-3 activity and a decrease in Bcl-2, which cau...

Journal: :Journal of Asian natural products research 2005
Yu Cao Fang Wang Hong-Yan Liu Zhao-Di Fu Rui Han

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a naturally occurring phytoalexin found in grapes and wine, and has been reported to exert a variety of important pharmacological effects. We have investigated the activity of resveratrol on proliferation and differentiation of the acute promyelocytic leukemia cell line NB4. The growth inhibitory properties of resveratrol appear to be due to its...

2017
Shih-Chao Lin Chi-Tang Ho Wen-Ho Chuo Shiming Li Tony T. Wang Chi-Chen Lin

BACKGROUND Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that causes severe morbidity and mortality. Up to date, there is no approved or licensed vaccine or antiviral medicines can be used to treat MERS-CoV-infected patients. Here, we analyzed the antiviral activities of resveratrol, a natural compound found in grape seeds and skin and in red wine, agains...

2012
HYOUN-JI KIM KWANG-MO YANG YOO-SOO PARK YOO-JIN CHOI JI-HYEON YUN CHEOL-HUN SON HONG-SUK SUH MIN-HO JEONG WOL-SOON JO

Resveratrol (3,4',5 tri-hydroxystilbene), a natural plant polyphenol, has gained interest as a non-toxic chemopreventive agent capable of inducing tumor cell death in a variety of cancer types. Several studies were undertaken to obtain synthetic analogues of resveratrol with potent anticancer activity. The aim of the present study was to investiga...

Journal: :Anticancer research 2009
Min Young Kim Laura J Trudel Gerald N Wogan

Although many studies have focused on anticarcinogenic properties of capsaicin and resveratrol, molecular mechanisms by which they selectively induce apoptosis are incompletely characterized. We examined the role of nitric oxide (NO) and influence of p53 status during apoptosis induced by these agents in two isogenic HCT116 human colon carcinomas, wild-type p53 (p53-WT) and complete knockout of...

2015
Forouzan Faghihzadeh Azita Hekmatdoost Payman Adibi

BACKGROUND Recent studies demonstrated that resveratrol has many therapeutic effects on liver disorders. Resveratrol significantly increased survival after liver transplantation, decreased fat deposition, necrosis, and apoptosis which induced by ischemia in Wistar rats. It provided liver protection against chemical, cholestatic, and alcohol injury. Resveratrol can improve glucose metabolism and...

2015
Sangiliyandi Gurunathan Jae Woong Han Eun Su Kim Jung Hyun Park Jin-Hoi Kim

OBJECTIVE Graphene represents a monolayer or a few layers of sp2-bonded carbon atoms with a honeycomb lattice structure. Unique physical, chemical, and biological properties of graphene have attracted great interest in various fields including electronics, energy, material industry, and medicine, where it is used for tissue engineering and scaffolding, drug delivery, and as an antibacterial and...

Journal: :Journal of immunology 2012
Lukas Bossaller Ping-I Chiang Christian Schmidt-Lauber Sandhya Ganesan William J Kaiser Vijay A K Rathinam Edward S Mocarski Deepa Subramanian Douglas R Green Neal Silverman Katherine A Fitzgerald Ann Marshak-Rothstein Eicke Latz

Fas, a TNF family receptor, is activated by the membrane protein Fas ligand expressed on various immune cells. Fas signaling triggers apoptosis and induces inflammatory cytokine production. Among the Fas-induced cytokines, the IL-1β family cytokines require proteolysis to gain biological activity. Inflammasomes, which respond to pathogens and danger signals, cleave IL-1β cytokines via caspase-1...

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