نتایج جستجو برای: apolipoprotein a1
تعداد نتایج: 44972 فیلتر نتایج به سال:
Background An unfavourable lipid profile has been associated with the increased risk of dementia or Alzheimer’s disease in both observational and genetic studies1,2. However, it is challenging to investigate each serum measure individually due high correlation between traits. We aimed discover causal associations genetically instrumented measures (low-density lipoprotein cholesterol (LDL-C), hi...
Introdaction: Lipid metabolism disorders, especially raised levels of cholesterol and triglycerides increases the risk of atherosclerosis. This study aimed to investigate the effect of training type including submaximal continuous and high-intensity interval training on hepatic gene expression of Apolipoprotein A‐I, and Apolipoprotein A‐II in male Wistar rats. Materials & Methods: This exper...
HDL has a key role in reverse cholesterol transport, mobilizing cholesterol from the peripheral tissues to liver. In this process, the ABC transporter A1 (ABCA1) protein controls the efflux of intracellular cholesterol to apoAI, the major apolipoprotein of HDL. Since ABCA1 mutations were discovered to cause Tangier disease, a rare recessive HDL deficiency, it has been speculated that sequence v...
AIMS To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles. METHODS AND RESULTS Extensive observational data, in which random non-fasting lipid profiles have been compared with those determined under fasting conditions, indicate that th...
BACKGROUND The purpose of the study was to investigate the relation of lipoprotein(a) and serum lipid parameters to restenosis after percutaneous transluminal coronary angioplasty (PTCA) and to assess the association of these same biochemical markers to coronary artery disease (CAD) in individuals with angiographically defined normal and diseased coronary arteries. METHODS AND RESULTS Sixty-t...
A critical event in the development of atherosclerosis is the recruitment of macrophages to the underlying epithelial layer of blood vessel walls and the uncontrolled uptake of oxi-dized/modified cholesterol. Continued accumulation of oxi-dized/modified cholesterol by macrophages and an associated inflammatory response leads to foam cell formation and the initiation of atherosclerosis. 1 Revers...
BACKGROUND Numerous studies have shown an inverse association between cholesterol´s concentration associated with High-Density Lipoprotein Cholesterol (HDL-C) and cardiovascular risk. The present study intends to investigate the possible relation between Apolipoprotein A (ApoA1) and HDL-C as a new strategy to reduce cardiovascular risk. AIM was determine the effect of ApoA1 in cholesterol ´s ...
RATIONALE High-density lipoprotein (HDL) is a heterogeneous population of particles. Differences in the capacities of HDL subfractions to remove cellular cholesterol may explain variable correlations between HDL-cholesterol and cardiovascular risk and inform future targets for HDL-related therapies. The ATP binding cassette transporter A1 (ABCA1) facilitates cholesterol efflux to lipid-free apo...
INTRODUCTION Despite high diabetes rates among Canadian First Nations people, little is known about their cardiovascular disease risk. Our aim was to describe the apolipoprotein profile with respect to cardiovascular risk in a Canadian First Nation community. METHODS In 2003, a representative sample of adult members of a Manitoba First Nation (N = 483) participated in a screening study for di...
BACKGROUND Serum amyloid A protein (SAA) is not only an inflammatory factor, but also an apolipoprotein that can replace apolipoprotein A1 (apoA1) as the major apolipoprotein of high-density lipoprotein (HDL), which has been linked to atherosclerosis. However, the relationship between genetic polymorphisms of SAA and the intima-media thickness (IMT) of the common carotid artery in healthy subje...
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