We applied a novel application of FLIM-FRET to in situ measurement and quantification of protein interactions to explore isoform specific differences in Aβ-ApoE interaction and ApoE tertiary conformation in senile plaques in human Alzheimer brain. ApoE3 interacts more closely with Aβ than ApoE4, but a greater proportion of Aβ molecules within plaques are decorated with ApoE4 than ApoE3, lending...

1 Tikkanen MJ. Immunogenetic polymorphism of apolipoprotein B in man. Studies with a monoclonal anti-Ag(c) antibody. Am HeartJ 1987;113:462-7. 2 Viikari J, Akerblom HK, Nikkari T, et al. Atherosclerosis precursors in Finnish children and adolescents. IV. Serum lipids in newborns, children and adolescents. Acta Paediatr Scand 1985;318 (suppl): 103-9. 3 Berg K. DNA polymorphism at the apolipoprot...

We have used human apolipoprotein cDNAs as hybridization probes to study the relative abundance and distribution of apolipoprotein mRNAs in rabbit tissues by RNA blotting analysis. The tissues surveyed included liver, intestine, lung, pancreas, spleen, stomach, skeletal muscle, testis, heart, kidney, adrenal, aorta, and brain. We found that liver is the sole or major site of synthesis of apoA-I...

Background: Apolipoprotein A2 (APOA2) is the second major apolipoprotein of the high-density lipoprotein cholesterol (HDL-C). The study aim was to identify APOA2 gene variation in individuals within two extreme tails of HDL-C levels and its relationship with HDL-C level. Methods: This cross-sectional survey was conducted on participants from Tehran Glucose and Lipid Study (TLGS) at Research Ins...

Background: The association between coronary artery disease and androgenic alopecia has been demonstrated, but few studies have focused on the mechanism of this association. The aim of this study was to evaluate the lipid profile in male pattern alopecia.Methods: In this case control study, 45 male patients with androgenic alopecia who were aged from 20 to 50 years and 45 men with a norma...

Background: The correlation between coronary artery disease and androgenic alopecia has been demonstrated, but the mechanism of this association still remains to be cleared. Objective: To investigate lipid profile, as an indicator of coronary artery disease, in women with female pattern alopecia. Methods: Fifty one women with female pattern alopecia and thirty one healthy women with normal hair...