Background: The link of the apolipoprotein (APOE) -ε4 allele to Alzheimer disease (AD) has led to studies investigating the role of apoE polymorphisms in Parkinson disease (PD). The authors hypothesized that any association between PD and APOE alleles and genotypes would be too small to be detected or precisely estimated by an individual case-controlled study. Method: The hypothesis was tested ...

The association between cerebrospinal fluid (CSF) amyloid beta (A?) A?38 or A?40 and brain grey- white matter integrity is poorly understood. We studied this in 213 cognitively normal 70-year-olds, subgroups defined by presence/absence of the APOE ?4 allele A? pathology: A??/APOE?, A?+/APOE?, A??/APOE+ A?+/APOE+. CSF was quantified using ELISA genotyping for performed. Low A?42 plaque pathology...

BACKGROUND The genes encoding myeloperoxidase (MPO) and alpha(2)-macroglobulin (A2M) are involved in molecular pathways leading to beta-amyloid deposition. Two polymorphic sites in these genes (MPO-G/A and A2M-Ile/Val) have been associated with Alzheimer disease (AD), but conflicting findings have been reported in populations with different ethnic backgrounds. OBJECTIVES To study the associat...

Background and Objective: Apolipoprotein E (APOE) plays important roles in lipoprotein metabolism and cardiovascular disease. Evidence suggests the APOE gene epsilon2/epsilon3/epsilon4 (ε2/ε3/ε4) polymorphisms might be associated with the susceptibility of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). However, no clear consensus has yet been established. Theref...

BACKGROUND Apolipoprotein E (APOE) polymorphism is associated with lipid levels. Some studies have reported that blood lipid response to diet or obesity varies depending on APOE genotypes. The aim of this study was to assess the effect of APOE genotypes, the intake of saturated fatty acids (SFA), and obesity on serum lipid levels in Lithuanian adult population. METHODOLOGY/PRINCIPAL FINDINGS ...