I. Wemmelund H, Høgh A, Hundborg HH, Thomsen RW, Johnsen SP, Lindholt JS. Statin use and rupture of abdominal aortic aneurysm. Br J Surg 2014; 101: 966–975. II. Wemmelund H, Høgh A, Hundborg HH, Johnsen SP, Lindholt JS. Preadmission use of renin–angiotensin blockers and rupture of abdominal aortic aneurysm: a nationwide, population-based study. Pharmacoepidemiol Drug Saf 2016; 25:141-50. III. W...

Aortic coarctation (AC) represents -7% of congenital cardiac diseases and is usually diagnosed in childhood or early adult Life, depending on the severity of obstruction and associated malformations. Left untreated fewer than 20% of patients survive to age 50. We describe a case of thoracic AC, diagnosed at age 61, in a woman with known hypertension since age 45. At age 56 the patient was admit...

We contrasted in normotensive and hypertensive rats the effect of inhibition of nitric oxide synthesis on isometric tension development by aortic rings bathed in Krebs' bicarbonate buffer. NG-Nitro-L-arginine methyl ester (L-NAME) (3 x 10(-4) mol/L) increased tension (82 +/- 11% of the response to 120 mmol/L potassium chloride) in rings of thoracic aorta taken from hypertensive rats 7 to 14 day...

A ten week old girl who had previously undergone a palliative procedure for the hypoplastic left heart syndrome had unrelieved aortic coarctation that did not respond to standard balloon dilatation. Complete relief of coarctation with prompt clinical improvement was achieved with placement of an 8 mm self-expanding stent. Transcatheter stent implantation may have a role in selected patients wit...

INTRODUCTION AND OBJECTIVES Stent implantation is an effective therapy for aortic coarctation and recoarctation. However, in adolescents and adults, aortic wall rupture and dissection can occur, as well as aneurysms during follow-up. In order to reduce these complications, we electively implant covered stents. METHODS Since 2005, we have performed the procedure using femoral access in 17 pati...

BACKGROUND The development of abdominal aortic aneurysm (AAA) is probably influenced by many factors. The role of some of these factors, such as intraluminal thrombus (ILT) or cystatin C serum levels, remains controversial. Proving their influence could have therapeutic implications for some patients with AAA. Associations between the rate of increase in diameter of an aneurysm and ILT, as well...

OBJECTIVES We sought to determine the prevalence and predisposing condition for aortic wall complications in adults with either repaired or non-repaired coarctation of the aorta. BACKGROUND Aortic wall complications may develop in adults with coarctation of the aorta, despite successful surgical repair in childhood. METHODS A total of 235 adults with coarctation (mean age 27 +/- 13 years) w...

We present the case of an asymptomatic 26-year-old female patient with a huge thoracic aneurysm discovered at a routine echo screening. The patient had previously been operated on for coarctation of the aorta in childhood and also had diagnosed bicuspid aortic valve. The operation was carried out in extracorporeal circulation at the 22(nd) week of gestation without any complications. A few mont...

BACKGROUND Many studies have been performed in order to model abdominal aortic aneurysm (AAA) in an experimental animal, most commonly in small laboratory animals. In our study, we tried to find the best AAA model in a pig by using various mechanical and enzymatic mechanisms. METHODS Twenty-two pigs were operated on. We combined 3 mechanisms of creating an AAA, using an intraluminal infusion ...

An abdominal aortic aneurysm (AAA) is defined as a permanent and irreversible localized dilatation of the abdominal aorta. A reliable, non-invasive method to assess the wall mechanics of an aneurysm may provide additional information regarding their susceptibility to rupture. Acoustic radiation force impulse (ARFI) imaging is a phenomenon associated with the propagation of acoustic waves in att...