La coartación de la aorta, es una cardiopatía congénita frecuente (aproximadamente 20 a 60 por cada 100,000 nacidos vivos) y se caracteriza estenosis aorta descendente, habitualmente distal al origen subclavia izquierda, altura inserción del ligamento arterioso. Hay un predominio sexo masculino está asociada con otros defectos congénitos, como bicúspide en el 50% los casos. Los pacientes aórtic...

In vitro experimental set-up is an important tool for investigating abdominal aortic aneurysm (AAA). Accurate reproduction of the physiological pulsatile flow waveform in aorta at various anatomic locations component these methods. The objective this study to establish generate a simulations aorta. was established by computer-controlled peristaltic pump and field circular straight pipe measured...

Introduction: Despite its rapid technological development and widespread uptake for thoracic aortic disease, an extremely tortuous anatomy is considered a contraindication endovascular repair procedure. We report case of successful using techniques to straighten aorta friendly. Methods: A 78-year-old man with frequent surgical history was admitted our outpatient clinic because dyspnea back pain...

BACKGROUND The natural history of thoracic aortic aneurysm is incompletely understood. Over the last 10 years, at Yale University we have maintained a large computerized database of patients with thoracic aortic aneurysms and dissections. Analysis of this database has permitted insight into fundamental issues of natural behavior of the aorta and development of criteria for surgical intervention...

Dilatation of the ascending aorta (AAD) is a prevalent aortopathy that occurs frequently associated with bicuspid aortic valve (BAV), the most common human congenital cardiac malformation. The molecular mechanisms leading to AAD associated with BAV are still poorly understood. The search for differentially expressed genes in diseased tissue by quantitative real-time PCR (qPCR) is an invaluable ...

BACKGROUND End-stage renal disease (ESRD) is strongly associated with arterial calcification of the tunica media, decreased vascular compliance and sudden cardiac death. Here, we analysed the distribution pattern of uraemic media calcification and concomitant inflammation in mice and men. METHODS Uraemia was induced in DBA/2 mice with high-phosphate diet. Subsequently, we analysed arterial me...

We investigated a possible contribution of nitric oxide (NO) and prostaglandins to the inhibitory effect of losartan on contractions to Ang I (10(-6) M) and Ang II (10(-7) M) with or without L-NAME (10(-4) M) or indomethacin (10(-5) M) in the aorta of WKY, SHR and hamster (n=7 each). Rings of thoracic aorta (2-mm long) were placed in a myograph (5 ml). Endothelium-dependent vasodilations were e...

We previously demonstrated that alpha1B-adrenergic receptor (AR) gene transcription, mRNA, and functionally coupled receptors increase during 3% O2 exposure in aorta, but not in vena cava smooth muscle cells (SMC). We report here that alpha1BAR mRNA also increases during hypoxia in liver and lung, but not heart and kidney. A single 2.7-kb alpha1BAR mRNA was detected in aorta and vena cava durin...

It has been proposed that a mass transfer phenomenon called concentration polarization of low-density lipoproteins (LDLs) may occur in the arterial system and is likely involved in the localization of atherogenesis. To test the hypothesis that concentration polarization of LDL may be suppressed by the helical flow pattern in the human aorta, hence sparing the ascending aorta from atherosclerosi...

1. The effect of cholesterol feeding during and after a period of protein malnutrition lasting 4 weeks was examined in the rat. Indices measured were plasma total cholesterol, triglycerides and protein levels, and aorta total cholesterol, triglycerides, hexosamine and hydroxyproline concentrations. 2. In both plasma and aorta, total cholesterol and triglycerides levels were higher in the low-pr...