Nephrotoxicity and hepatotoxicity are frequently seen adverse effects during cisplatin chemotherapy. In this study, we investigated the of agomelatine on cisplatin-induced toxicity in kidney liver. Animals were administered with a single dose (7 mg/kg, i.p.) treated (20 40 p.o) for seven days. Renal hepatic functions evaluated by measuring concentrations creatinine, BUN, AST ALT serum. Oxidativ...

BACKGROUND Nitric oxide inactivation by superoxide impairs endothelium-dependent vasodilation and plays a role in various forms of hypertension. Almost no data exist regarding hypertension secondary to chronic renal failure. Previous studies have shown that endothelium-related relaxations, secondary to decreased nitric oxide bioactivity, are impaired in resistance vessels from rats 3 to 10 days...

(1) Background: This paper aims to assess the existence of significant differences between two dietary regimes (omnivorous vs. semi-vegetarian) with reference some oxidative stress markers (SOD, GPx, TRxR, GR, AGEs, and AOPPs) using non-parametric combination methodology based on a permutation test. (2) Methods: At endocrinology unit Messina University Hospital, hundred subjects were asked fill...

BACKGROUND Women have enhanced triglyceride (TAG) removal from the circulation following consumption of high-fat loads, potentially leading to decreased reactive oxygen and nitrogen species (RONS) generation. This may have implications related to long-term health outcomes. We examined the oxidative stress response to high-fat feeding between men and women to determine if women are less prone to...

BACKGROUND Many changes can occur in proteins, including amino acid modification, fragmentation, changes in absorption and fluorescence spectra and others. All these modifications can be used as markers of protein damage by free radicals. AIM OF THE WORK The aim of the present study was to investigate the antioxidant activities of the aqueous extracts of dry green of pods Phaseolus vulgaris, ...

Objective: The aim of the study was to explore mutual relationship between oxidative stress, inflammation and metabolic biomarkers in subjects with prediabetes (PRE), newly diagnosed type 2 diabetes patients (NT2D) overt (T2D) using principal component analysis (PCA) as a thorough statistical approach.
 Patients Methods: Glycated hemoglobin, lipid parameters, (IL-6, CRP fibrinogen) stress ...

Fipronil is widely used against insects in agriculture and ectoparasites domestic areas veterinary medicine. However, fipronil may influence non-target species as a result of the contamination aquatic ecosystems. The present study aimed to investigate acute sublethal effects freshwater mussels (Unio delicatus), species, with physiological, antioxidant action mechanisms histopathological observa...

The purpose of the study was to conduct a comparative synthesis pro-inflammatory cytokines, state cellular immunity, free radical oxidation reactions and antioxidant protection in patients with pulmonary tuberculosis without relapse. Material methods. carried out on two groups patients: first group basic which included 39 relapsed (TBR); 2nd control non-relapsed (TB). Pro-inflammatory cytokines...