Prolastin is a commercially available form of alpha-1-antitrypsin (AAT) that is derived from pooled human plasma and used for treatment of severe alpha-1-antitrypsin deficiency (AATD). We describe a patient with AATD who developed presumed hypersensitivity vasculitis (HV) following a Prolastin infusion. Hypersensitivity vasculitis (HV), or cutaneous vasculitis, is characterized by inflammation ...

Polymorphonuclear leukocytes have the capacity to supply proteolytic enzymes capable of generating kinin activity from a plasma protein substrate, kininogen, under diverse reaction conditions (1-3). Experiments, initially directed toward the mechanism of neutrophil-dependent kinin generation, have uncovered a different system which is controlled by ec-l-antitrypsin. Incubation of crude neutroph...

I t has been a well known fact for some time that blood serum has the property of retarding the digestive activity of trypsin. We have, however, no satisfactory information regarding either the nature of the substance which effects the retardation or the type of chemical reaction involved in the process. At one time the inhibitory agent was thought to be an immune antibody and in accordance wit...