one of the most common endocrine disorders in women of reproductive age is polycystic ovary syndrome (pcos) which its prevalence is reported around 6.5-8% (1). some clinical trials assessed association between pcos and other autoimmune related endocrinopathies such as impaired glucose tolerance (igt), type 2 diabetes mellitus and thyroid dysfunction with controversial results (2). some investig...

Normal in vitro thyroid peroxidase (TPO) iodide oxidation activity was completely inhibited by a hydrolyzed TPO preparation (0.15 mg/ml) or hydrolyzed bovine serum albumin (BSA, 0.2 mg/ml). A pancreatic hydrolysate of casein (trypticase peptone, 0.1 mg/ml) and some amino acids (cysteine, tryptophan and methionine, 50 microM each) also inhibited the TPO iodide oxidation reaction completely, wher...

The knowledge about dietary habits and their influence in the development of autoimmune thyroid disease is insufficient. The aim of this study was to analyse the association of dietary factors and plasma thyroid peroxidase antibodies (TPO-Ab) and/or thyroglobulin antibodies (Tg-Ab). The study enrolled 1887 participants originating from the South Croatia. Participants with elevated plasma TPO-Ab...

Background. Postpartum thyroiditis (PPT) is a common triphasic autoimmune disease in women with thyroid peroxidase (TPO) autoantibodies. This study evaluated women's thyroid disease symptoms, physical findings, stress levels, and thyroid stimulating hormone (TSH) levels across six postpartum months in three groups, TPO negative, TPO positive, and PPT positive women. Methods. Women were recruite...

Thyroid Peroxidase (TPO), a dimeric, membrane-bound glycoprotein found in the thyroid follicular lumen, catalyses the biosynthesis of thyroxine, and is also a major autoantigen in autoimmune thyroid disease (AITD). TPO molecules undergo posttranslational modifications such as glycosylation, heme incorporation, dimer formation, and proteolytic processing in the N-terminal region. Due to propepti...

OBJECTIVE The study was designed to evaluate the relationship between thyroid antibodies and gland dysfunction, with the aim of finding a clinically useful threshold value of thyreoperoxidase antibodies, which could prove to be predictive for thyroid failure. MATERIAL AND METHODS The study was conducted on 99 women, ages ranging from 18-91 years (mean age: 45.5 ±17.0), were treated as outpati...

OBJECTIVE Thyroid dyshormonogenesis is a genetically heterogeneous group of inherited disorders in the enzymatic cascade of thyroid hormone synthesis that result in congenital hypothyroidism (CH). Thyroid peroxidase gene (TPO) mutations are one of the most common causes of thyroid dyshormonogenesis. The aim of this study was to identify TPO gene defects in a cohort of patients with thyroid dysh...

Background: Evaluation of thyroid disorder in pregnancy is essential for maternal health, obstetrical outcome and neurodevelopment the child. Euthyroid pregnant women having positive peroxidase antibodies have an elevated risk miscarriage, premature birth, gestational hypertension, intrauterine fetal demise. Thyroid autoimmunity (TAI) subclinical hypothyroidism (SCH) been connected with adverse...

Thrombopoietin (TPO) is a hematopoietic growth factor that stimulates megakaryocytopoiesis and platelet production in vivo and promotes the development of identifiable megakaryocytes in vitro. We have developed a murine monoclonal antibody, BAH-1, raised against human megakaryocytic cells, which specifically recognizes the c-Mpl receptor and shows agonist activity by stimulating megakaryocytopo...

BACKGROUND A case report of Hashimoto's thyroiditis-associated ophthalmopathy that masqueraded as double elevator palsy in 1 eye. CASE PRESENTATION A 54-year-old woman presented to our strabismus clinic with diplopia for 1 year. She was diagnosed with double elevator palsy in the left eye. The forced duction test yielded positive findings for the inferior rectus of the left eye; hence, comput...