1. Metamizole (synonym: dipyrone) is a pyrazolone non-steroidal anti-inflammatory drug (NSAID). In veterinary medicine it is available as a mono-preparation containing 500 mg/ml metamizolesodium. There are also combination products containing 500 mg/ml metamizole + 4 mg/ml of an antispasmodic agent such as butylscopolaminium bromide. Metamizole preparations are indicated for use in horses, catt...

Onion (Allium cepa) bulb from Liliaceae has antioxidant, spasmolytic and antihypertensive activities. The aim of present study was to investigate the antispasmodic effect of onion peel on rat ileum contractility. Onion peel powder was extracted by maceration in 70% alcohol for 72 h. A terminal portion of ileum from male Wistar rat was dissected and its contractions were recorded isotonically in...

1,3,4-oxadiazole derivatives constitute a group of biologically important compounds that have been used as analgesic, anti-inflammatory, antibacterial, antifungal, antispasmodic, or psychotropic drugs in addition to their role plant growth regulation and monoamine oxidase inhibition. This study focused on the use microwaves synthesis oxadiazole containing thiazolidinediones, which are promising...

The diagnosis and treatment of cerebellar atrophy remain challenging owing to its nonspecific symptoms laboratory indicators. Three patients with spinocerebellar ataxia type 8 caused by ATXN8OS were found among the 16 people in studied family. clinical manifestations included progressive spastic paraplegia lower extremities, mild ataxia, cognitive impairment, atrophy. After administering antisp...

Thymus vulgaris L. commonly known as thyme or garden belonging to family Lamiaceae is a pleasant smelling flowering perennial shrub, cultivating all over the world. Thyme has great importance due possibility of its use in various applications, food additives, medicines and cosmetic industry. leaves are highly aromatic therefore used fresh dried seasoning variety culinary applications including ...

There are several data in the literature indicating a great variety of pharmacological activities of Curcuma longa L. (Zingiberaceae), which exhibit anti-inflammatory, anti-human immunodeficiency virus, anti-bacteria, antioxidant effects and nematocidal activities. Curcumin is a major component in Curcuma longa L., being responsible for its biological actions. Other extracts of this plant has b...

Morindacitrifolia, also known as noni belongs to the family Rubiaceae has been in high demand in yurvedic medicine. It has been used long since in various cultures as a medicine for cure of various ailments. This review attempts to analyze the evidence for the claim as a therapeutic cure for many diseases. This review article is presented to compile all the updated information on its phytochemi...

Kalmegh (Andrographis paniculata Nees) has wide range of medicinal and pharmacological applications. It is used in different traditional systems of medicine and exhibits anti-inflammatory, anti-HIV, antibacterial, antioxidant, antiparasitic, antispasmodic, antidiabetic, anticarcinogenic, antipyretic, hepatoprotective, nematocidal and various other activities. It is a potent scavenger of a varie...

Vettumaran Gutika produced moderate CNS depressant effect, prolonged pentobarbitone and diazepam induced sleep, produced initial depression followed by stimulation of SMA in mice. It did not effect SCR and CAR in rats, reserpine effects in mice and threshold of tail-flick response in rats. It failed to protect rats and mice aginst Electro, pentylenetetrazol and strychnine induced convulsions an...

The Lippia alba (Mill.) N.E. Brown (Verbenaceae) species, has effects sedative, analgesic and spasmolytic properties. This study had as its main objective to evaluate the essential oil of L. alba (EOLa) effect and that of its main constituents, citral and limonene, over tracheal smooth muscle from Wistar rats. EOLa, citral and limonene promoted relaxation of tracheal smooth muscle in contractio...