Clozapine is more efficacious than first-generation antipsychotics for positive and negative symptoms, although it is related with serious adverse effects. Because of this profile, it could also have an impact on cognition. Therefore, we evaluated learning ability of 31 treatment-resistant individuals with SZ using clozapine uninterruptedly for 18.23 ± 4.71 years and 26 non-treatment-resistant ...

Neuroleptic-induced tardive dyskinesia, which often appears in middle-aged and older adults early in the course of treatment with low doses of conventional antipsychotics, is 5 to 6 times more prevalent in elderly than in younger patients. In addition to age, other risk factors for tardive dyskinesia include early extrapyramidal symptoms (EPS), cumulative amounts of neuroleptics, duration of ne...

The prevalence of schizophrenia among hearing impaired is nearly equal to that of the general population [1]. Both bilateral and unilateral auditory hallucinations in hearing impaired are thought to predispose them to develop schizophrenia [2]. Auditory hallucinations in patients with normal hearing may inadequately respond to antipsychotic medication [3]. There is no report that hallucinations...

There is a need for effective medications to treat patients living with schizophrenia or bipolar I disorder (BD-I). LYBALVI®, combination of olanzapine and samidorphan, was recently approved the treatment adults BD-I. We estimated budgetary impact adding LYBALVI formulary from Commercial, Medicaid, Medicare perspectives in United States (US). A budget model (BIM) 3-year time horizon developed h...

Introduction Nowadays, In the exercise of psychiatric clinical activity, prescription atypical antipsychotics is a widespread practice. However, despite approval in treatment psychoses and bipolar affective disorder, where its effectiveness clearly demonstrated, these drugs are off-label prescribed most situations. Objectives This work aims to clarify which frequent conditions their more common...

In this review report, an attempt made to present overview of schizophrenia & those drugs which are used in treatment psychiatric disorders as well some treatments for psychosis. 1908, the word was coined by Eugen Bleuler (Swiss psychiatrist). The use antipsychotics medication began from 1933 France. Laborit and Huguenard administrated aliphatic Phenothiazine, Chlorpromazine during surgery ...

INTRODUCTION Providing comprehensive services for about 400 patients in the South Herefordshire area, the community mental health team manages cases of varying severity and complexity, ranging from Schizophrenia, to neuroses and disorders of adult personality. Antipsychotic medication remains a mainstay of treatment and management for patients under the team case load; hence a need exists for a...

Background:Olanzapine is a highly tolerable and easily affordable atypical antipsychotic drug which has been commonly prescribed in both inpatient and outpatient settings for several mental disorders. Olanzapine overdose is commonly seen in psychiatric patients, who attempt suicide by intoxicating themselves with their own prescribed medications. Increased olanzapine use is associated with incr...

INTRODUCTION Patients on levodopa therapy frequently require additional antipsychotic pharmacotherapy. However, consideration must be given to antagonistic interactions on dopamine receptors between levodopa and antipsychotics, and efficacy and safety of such combinations. We therefore aimed to explore the practice and rationale of coprescription between levodopa and antipsychotics in psychiatr...