The early reports on the use of Thephorin,* a hydrogenated phenyl-pyridindene derivative, seemed to indicate that it was an ideal antipruritic, i.e., it effectively and consistently relieved the sensation of itching while producing relatively few or no untoward side effects. Lehmann et al. (1) reported that it is very potent in antagonizing important physiologic effects of histamine on smooth m...

BACKGROUND Pruritus is the most common and distressing skin symptom, and treatment of itch is a problem for thousands of people. The currently available therapies are not very effective. Therefore there is an urgent need to find new effective topical drugs against itching. OBJECTIVE We conducted two separate studies to evaluate the efficacy of topically applied naltrexone, an opioid receptor ...

Pruritus (itch sensation) is the most common side effect associated with spinal administration of morphine given to humans for analgesia. A variety of agents have been proposed as antipruritics with poorly understood mechanisms and they are effective with variable success. -Opioid agonists possess several actions that are opposite to -opioid agonists. We proposed to investigate the role of -opi...

Topicality. Сlemastine fumarate (tavegil)-1-methyl-2 [2-α-methyl-p-chlorobenzhydryloxy)-ethyl]-pyrrolidine is the first generation H1-histamine receptor blocker. selectively inhibits histamine H1 receptors and reduces capillary permeability. The drug has a pronounced anti-allergic antipruritic effect. Clemastine prevents development of vasodilation smooth muscle contraction induced by histamine...

Resorcinol is a dihydric phenol having the hydroxyl group at 1 and 3 positions in the benzene ring [1]. It occurs naturally in argan oil as main natural phenol. It is white crystalline powder having a faint odour and bitter-sweet taste [2]. It is used as a chemical intermediate in manufacturing of pharmaceuticals, dyestuffs and fungicides such as p-aminosalicylic acid, hexylresorcinol and light...

To the Editor: Clinical trials to assess antipruritic effect of a treatment commonly use numerical rating scale (NRS) ranging from 0 (no itching) 10 (worst imaginable evaluate worst itch intensity. However, for drug be clinically relevant, magnitude reduction in NRS scores must represent meaningful improvement patients. Clinically changes with respect have been characterized dermatologic condit...

otic medications are selected for cleaning, drying, and anti inflammatory or anti microbial properties. Parasiticidal agents are sometimes included, however they are often unnecessary. Vehicles and dispersion agents are also important in otic topicals. Topical glucocorticoids are valuable in most cases of otitis externa even when infection is present. Glucocorticoids have antipruritic, anti-inf...

Heparin is an injectable anticoagulant that prevents coagulation. There are presently high and low molecular heparins as well as synthetic pentasaccharide inhibitors. Given its ubiquitous use in sensitive medical states, there is a high concern for safety with this drug. Heparin can induce several distinct immune-mediated reactions. There are several options to consider when heparin allergy occ...

EGR1 encodes a transcription factor containing three zinc-finger (ZF) DNA-binding domains of the Cys2-His2 type. It is rapidly induced by variety extracellular stimuli and involved in multiple physiological processes, including apoptosis, cell proliferation, inflammation (Li et al., 2019Li T.T. Liu M.R. Pei D.S. Friend or foe, role EGR-1 cancer.Med Oncol. 2019; 37: 7Crossref PubMed Scopus (24) ...