نتایج جستجو برای: antiplasmodial activity
تعداد نتایج: 1134718 فیلتر نتایج به سال:
4-Nerolidylcatechol (1) is an abundant antiplasmodial metabolite that is isolated from Piper peltatum roots. O-Acylation or O-alkylation of compound 1 provides derivatives exhibiting improved stability and significant in vitro antiplasmodial activity. The aim of this work was to study the in vitro inhibition of hemozoin formation, inhibition of isoprenoid biosynthesis in Plasmodium falciparum c...
Understanding the molecular defense mechanism of macrophages and identifying their effector molecules against malarial parasites may provide important clues for the discovery of new therapies. To analyze the immunological responses of malarial parasite-induced macrophages, we used DNA microarray technology to examine the gene profile of differentiated macrophages phagocytizing Plasmodium falcip...
The search for safe antimalarial compounds acting against asexual symptom-responsible stages and sexual transmission-responsible forms of Plasmodium species is one of the major challenges in malaria elimination programs. So far, among current drugs approved for human use, only primaquine has transmission-blocking activity. The discovery of small molecules targeting different Plasmodium falcipar...
Background: Malaria is a parasitic infection that common in the tropical and sub-tropical regions of world. It estimated to kill one million individuals annually. Detarium microcarpum (Fabaceae family) used traditionally for treatment malaria, diabetes, hypertension, convulsions, pneumonia, leprosy, meningitis. The purpose this research was evaluate antiplasmodial potential safety profile metha...
A new aporphine alkaloid, 7-epi-duguetine (1) together with one known alkaloid, dicentrinone (2), and four known flavonoids, quercetin 3,7-dimethyl ether 3′-O-α-L-rhamnopyranosyl-(12)-β-D-glucopyranoside (3), galangin 5-methyl ether (4), 5,7-dimethoxy-3-hydroxyflavone (5), and 3,5,7-trimethoxyflavone (6), were isolated from the leaves of Dasymaschalon acuminatum, a new plant species which has ...
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