The researches in the dynamic changes of the progress of HSCs aging are very limited and necessary. In this study, male C57BL/6 mice were divided into 5 groups by age. We found that the superoxide damage of HSPCs started to increase from the middle age (6 months old), with notably reduced antioxidation ability. In accordance with that, the senescence of HSPCs also started from the middle age, s...

Epidemiologic studies suggest a link between infection/inflammation and atherosclerosis. During the acute-phase response to infection and inflammation, cytokines induce tissue and plasma events that lead to changes in lipoprotein. Many of these changes are similar to those proposed to promote atherogenesis. The changes of lipoproteins during infection and inflammation are reviewed with a focus ...

A supported nanoparticle is dynamic in reaction conditions, but how this dynamic behavior is influenced by the support remains elusive. Using the stochastic surface walking global optimization method, herein, we report the structure, thermodynamics and catalytic properties of Pt nanoparticles inside and outside a carbon nanotube (CNT). We reveal that confined metal nanoparticles are, surprising...

Ziyuglycoside II is an active compound of Sanguisorba officinalis L. that has anti-inflammation, antioxidation, antibiosis, and homeostasis properties. We report here on the anticancer effect of ziyuglycoside II on human gastric carcinoma BGC-823 cells. We investigated the effects of ziyuglycoside II on cell growth, cell cycle, and cell apoptosis of this cell line. Our results revealed that ziy...

Abstract Selenium (Se) is an essential micronutrient for human biology that executes its functions as the amino acid selenocysteine via selenoproteins, which have important in, example, antioxidation, immunomodulation, thyroid metabolism, and fertility. Se nutritional status assessed using quantification of blood biomarkers, are influenced by several factors, including diet, age, gender, smokin...