BACKGROUND AND PURPOSE Early reperfusion is the most effective therapy for both acute brain and cardiac ischemia. However, the cervicocephalic circulatory bed offers more challenges to recanalization interventions. The historical development of reperfusion interventions has not previously been systematically compared. METHODS Medline search identified all multi-arm, controlled trials of coron...

The aim of the study was to analyze literature data regarding pathogenetic role insulin signaling disorders and diabetes-associated hyperglycemia in mechanisms diabetic encephalopathy hypersensitivity brain ischemia-reperfusion.
 Conclusion. Analysis shows a number common links between pathogenesis ischemic-reperfusion injury, which may, some extent, explain predisposition diabetics acute ...

Reperfusion of ischemic myocardium is crucial for salvaging myocardial cells from ischemic cell death. However, reperfusion itself induces various deleterious effects on the ischemic myocardium. These effects, known collectively as reperfusion injury, comprise stunned myocardium, reperfusion-induced arrhythmia, microvascular reperfusion injury, and lethal reperfusion injury. No approach has pro...

objective(s): intestinal ischemia-reperfusion is a major problem, which may lead to multiorgan failure and death. the aim of this study was to evaluate the protective effects of dexmedetomidine on cell proliferation, antioxidant system, cell death, and structural integrity in intestinal injury induced by ischemia-reperfusion in rats. materials and methods: animals were randomized into three gro...

objective(s): ischemia/reperfusion (i/r) injury of spinal cord is leading to the paraplegia observed. in this study, we investigated the protective effect of the saffron extract on spinal cord i/r injury. materials and methods: thirty five male sprague-dawley rats were divided into 5 groups: intact, sham surgery, normal saline (ns), low dose saffron aqua extract, high dose saffron aqua extract....

introduction: inhibition of renin angiotensin system represents an important approach in the management of cardiovascular diseases. the aim of this study was to explore the effects of pretreatment with non-hypotensive dose of angiotensin converting enzyme (ace) inhibitor, ramiprilat and angiotensin type 1 (at1) receptor blocker, losartan on myocardial infarct size and arrhythmias in a rat model...

BACKGROUND The role of ischemia reperfusion contributing to functional impairment in lower extremity peripheral arterial disease (PAD) patients has not previously been elucidated. The evaluation of gait variability patterns has proven useful in many pathologic populations. Therefore, the purpose of this study is to isolate and determine the specific effect of the acute reperfusion phase of isch...

AIMS Ischaemia-reperfusion provokes barrier failure of the coronary microvasculature, impeding functional recovery of the heart during reperfusion. The aim of the present study was to investigate whether the stimulation of cGMP signalling by activation of soluble guanylyl cyclase (sGC) can reduce reperfusion-induced endothelial intercellular gap formation and to determine whether this is due to...

BACKGROUND AND PURPOSE Most experimental models of cerebral ischemia use mechanical methods of occlusion and reperfusion. However, differences between mechanical reperfusion versus clot thrombolysis may influence reperfusion injury profiles. In this study we compared blood flow recovery, blood-brain barrier (BBB) permeability, and matrix metalloproteinase-9 (MMP-9) expression in cortex after me...

No reflow after acute myocardial infarction is an important predictor of infarct size and clinical outcome. However, the exact relationship between no reflow and infarct size remains to be determined, particularly because no reflow may progress during the time course of reperfusion. Control groups of five previous protocols using the anesthetized, open-chest rabbit model of coronary artery occl...