Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis is a life-threatening disease characterized by rapidly progressive glomerulonephritis (RPGN) and diffuse alveolar hemorrhage (DAH). Glucocorticoids and immunosuppressants are commonly used to treat this disease but may induce irreversible side effects, particularly in elderly patients. We herein report the case of a 76-year-ol...

Pneumatosis intestinalis is a characteristic imaging phenomenon indicating the presence of gas in the bowel wall. The link between pneumatosis intestinalis and various kinds of autoimmune diseases has been reported anecdotally, while information regarding the cases with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis complicated by concurrent pneumatosis intestinalis is lacki...

Introduction Indirect immunofluorescence remains the gold standard method for the detection of antineutrophil cytoplasm antibody (ANCA). A recommended method for detection of ANCA by indirect immunofluorescence was described in the First International Workshop on ANCA in 1988 and the approach described here is based on that method.' Increasingly, solid phase assays (enzyme linked immunosorbent ...

BACKGROUND AND OBJECTIVES Only rare cases of concurrent membranous glomerulonephritis (MGN) and antineutrophil cytoplasmic antibody (ANCA)-associated necrotizing and crescentic glomerulonephritis (NCGN) have been reported. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS The authors report the clinical and pathologic findings in 14 patients with MGN and ANCA-associated NCGN. RESULTS The cohort...

INCE THE ORIGINAL description of the clinical releS vance of antineutrophil cytoplasmic antibodies (ANCA) testing for patients with vasculitis and glomerulonephritis, antibodies directed against different enzymes in granulocyte granules have been the subject of many ongoing studies.' Although the state of the art has been reviewed previously,2" new findings over the last 2 years reflect the wid...

Antineutrophil cytoplasmic antibodies (ANCA) is usually considered to be associated with autoimmune neutropenia, but the association between ANCA and autoimmune pulmonary hemorrhage has been rarely reported. In this case, we reported a 49 year-old woman with paroxysmal cough and hemoptysis. The symptom didn’t improve from any anti-infection treatment. Further autoantibodies analysis reveals ANC...

PURPOSE OF REVIEW This review aims to provide a state-of-the-art perspective on the role of kidney transplantation in cases of end-stage kidney disease due to antineutrophil cytoplasmic antibody (ANCA) vasculitis. We focus on patient and graft survival in recent years, timing of transplant, impact of ANCA status, and relapse of vasculitis in the allograft. RECENT FINDINGS Graft and patient ou...

INTRODUCTION Propylthiouracil (PTU) is commonly used to treat hyperthyroidism and can induce antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Although this is a rare side effect, ANCA-associated vasculitis can progress to severe disease if its diagnosis and treatment are delayed, leading to a poor prognosis. CASE PRESENTATION A 43-year-old woman with Graves' disease developed...

Levamisole-adulterated cocaine has increased in prevalence over the last decade and is known to be associated with antineutrophil cytoplasmic antibodies (ANCA). Dermatologic manifestations of levamisole exposure, including cutaneous vasculitis, are widely appreciated; less is known about its effects on the kidney. We report two cases of patients with a history of cocaine abuse and levamisole-in...

A 60-year-old man was admitted to our clinic with dyspnea, hemoptesis, anuria, nephritic syndrome, and a positive myeloperoxidase antineutrophil cytoplasmic antibody titer. He was diagnosed with antineutrophil cytoplasmic antibody-associated vasculitis due to Wegener granulomatosis, microscopic polyangiitis, or drug induction. Unexpectedly, histopathologic examination of the kidney biopsy speci...