The cytotoxicity of the clinically important antineoplastic quinones doxorubicin, mitomycin C, and diaziridinylbenzoquinone for the Ehrlich ascites carcinoma was significantly reduced or abolished by the antioxidant enzymes catalase and superoxide dismutase, the hydroxyl radical scavengers dimethyl sulfoxide, diethylurea, and thiourea, and the iron chelators deferoxamine, 2,2-bipyridine, and di...

background: high prevalence of risky behaviors in alcohol dependents have been shown in several studies, but correlation between alcohol abuse and risky behaviors and relapse in patients with opiate dependence has been less investigated. this study aimed to determine the effect of alcohol abuse in rate of risk-taking behaviors in opiate dependents patients treated on maintenance program in nort...

The triazole core is one of the most imperative and well known heterocycles which composed nitrogen atom forms natural products with medicinal claims. Triazole moiety present as a principal structural component in drug categories such antimicrobial, anti-inflammatory, analgesic, antineoplastic, antimalarial, antiviral, antihypertensive, local anaesthetic, antianxiety, anti-Parkinson′s, antidepr...

Purpose. The primary objective of this study was to compare the levels of environmental contamination before and after the introduction of PhaSeal (closed-system drug transfer device) in two hospital pharmacies. Our secondary objective was to assess the impact of the device on the duration of drug preparation compared to procedures involving the use of needles and syringes. Methods. The study i...

Background: Opioid abuse is common in Iran. In recent years, methadone maintenance therapy (MMT) has gained popularity in this country. This study aimed at evaluation concurrent abuse of alcohol in patients under MMT. Methods: A predesigned questionnaire was developed and completed after obtaining verbal consent among 49 subjects under MMT in Kian Rehabilitation Centre during January 2014. Resu...

Breast cancer is the most common neoplasm and leading cause of death in women worldwide. Although 5-fluorouracil a conventional chemotherapeutic agent for breast treatment, its use may result severe side effects. Thus, there widespread interest lowering drawbacks, without affecting therapeutic efficacy by concomitant with natural products. Herein, we aimed at evaluating whether α-mangostin, ant...

individuals handling antineoplastic drugs or their wastes may absorb these potent genotoxic agents. the effects of handling antineoplastic drugs were examined in a group of 24 nurses working in the hematology and oncology departments of two different university hospitals in shiraz (iran) and in a group of 18 unexposed nurses as control group. the cytogenetic repercussions of exposure were asses...

Recent progress in cancer treatment has increased the use of oral antineoplastic agents. It is now estimated that at least 25% of the existing antineoplastic agents are planned to be used as oral agents and this mode of administration is likely to increase in the coming years. The use of oral anti- neoplastic agents affects many aspects of cancer treatment, and despite advantages, it also poses...

Several anticancer drugs display characteristics that make them suitable candidates for therapeutic drug monitoring (TDM), including substantial pharmacokinetic variability and a narrow therapeutic index. However, concentration-effect relationships (pharmacodynamics) of most antineoplastic agents have not been well defined, thus limiting the widespread clinical application of TDM for cancer che...