The present study was conducted to investigate the antimutagenic potential of the methanolic extract from the leaves of sweet potato (Ipomea batatas, IB) with the SOS chromotest (umu test) and Salmonella typhimurium TA 98 and TA 100. The anticarcinogenic effects were also studied by calculation of the IC50 on human cancer cell lines and investigating the function of gap junction in rat liver ep...

The global pollution of environment urges the screening effective natural protectors for correc-tion toxic and genotoxic action xenobiotics. Medicinal herbs contain a complex biologically ac-tive compounds that are potential sources such protective agent. In current study mutagenic antimutagenic activity alcoholic extracts peppermint (Mentha piperita L.) thyme (Thymus vulgaris L.), family Lamia...

The cloning of single cells in agar was employed to study the effect of the addition of quinacrine hydrochloride to cultures of L1210 cells on the frequency of the mutation to resistance to cytarabine (ara-C). In three independent experiments this frequency was reduced 5to 16-fold after prolonged culture in the presence of quinacrine. Attempts to demonstrate a concomitant increase in the number...

Flavonoids occur in most plant species, and account for a significant percentage of the chemical constituents of some; e.g. dried green tea leaves contain approximately 30% flavonoids by weight. Flavonoids have been shown to have antibacterial, anti-inflammatory, antiallergic, antimutagenic, antiviral, antineoplastic, anti-thrombotic, and vasodilatory activity. The potent antioxidant activity o...

Peganum harmala is a plant that is traditionally used as an analgesic, anti-inflammatory, antibacterial, antioxidant, anti-helmintic, and antimutagenic agent. Moreover, it is used to treat a variety of human ailments, including depression. This study was conducted to investigate the antidiabetic activity of hydro alcoholic extract of this herb. A hydro alcoholic extract from seeds of this herb ...

Small molecules that interact with DNA are known to be effective as anticancer and antimicrobial agents. Therefore it is significant search for new interacting potential therapeutic In this study, we aimed investigate interactions of novel fluorine substituted imine compound DNA, (E)-2-((3,5-bis(trifluoromethyl) phenylimino)methyl)-4,6-dimethoxyphenol, its biological activities. the were invest...