A simple, efficient, and mild procedure for a solvent-free one-step synthesis of various 4,4'-diaminotriarylmethane derivatives in the presence of antimony trichloride as catalyst is described. Triarylmethane derivatives were prepared in good to excellent yields and characterized by elemental analysis, FTIR, (1)H and (13)C NMR spectroscopic techniques. The structural and vibrational analysis we...

to the preparation of triaryl-stibiues. Later, Grignard's reaction gave rise to the preparation of triphenvl-stibamines. Most of the present development of the organic-antimony derivatives, however, is due to the work done by Chemische, Fabrik Von Heyden who discovered the process of introducing into the aromatic nucleus the antimonial group through the agency of the diazoreaction. Great impetu...

OBJECTIVES Many kinds of heavy metals are used in industry; thus, it is important for us to clarify their toxicity. For example, lead, which is a component of solder, is notorious for its neurotoxicity, and substitute materials have been sought for many years. Therefore, we examined the genotoxicity of lead and also those of metallic bismuth, indium, silver and antimony which are possible subst...

The effect of additions of antimony (0.05% Sb) to silicon steel on the improvement of the electrical properties of non-oriented steel sheet was investigated. Measurements of surface segregation of Sb were performed under UHV conditions in the temperature range from 450 to 900 OC, using AES and TDS. Maximum equilibrium surface segregation of antimony was determined at 700 OC. At higher temperatu...

The possibility that the high frequency of treatment failures in Indian kala-azar might be due to infection with antimony-resistant strains of Leishmania donovani has not been experimentally addressed. L. donovani isolates were obtained from splenic aspiration smears of 24 patients in Bihar, India, who either did not respond (15) or did respond (9) to 1 or more full courses of treatment with so...

Widespread antimonial resistance in anthroponotic visceral leishmaniasis (VL) makes it critical to monitor the susceptibility of prevailing field isolates to upcoming antileishmanials in order to frame the right treatment policies to protect these drugs against development of resistance. We aimed to generate the baseline data on natural in vitro susceptibility to paromomycin and sitamaquine in ...

Thin films of CuSbS2, a potential candidate for absorber layer in thin film solar cells, were successfully deposited on soda lime glass substrates by using spray pyrolysis and the effect of variation of antimony concentration on the structural, morphological and optical properties were investigated. An aqueous solution of precursor containing cupric chloride, antimony acetate and thiourea was u...

Pentavalent antimony, as meglumine antimoniate (Glucantime) or sodium stibogluconate (Pentostam), is the main treatment for leishmaniasis, a complex of diseases caused by the protozoan Leishmania, and an endemic and neglected threat in Brazil. Despite over half a century of clinical use, their mechanism of action, toxicity and pharmacokinetic data remain unknown. The analytical methods for de...

We used instrumental neutron activation analysis (INAA) to determine antimony in small quantities of hair from individuals living in an area of endemic leishmaniasis. The groups studied were 12 patients undergoing treatment with N-methylglucamine antimoniate, 34 patients who had received such treatment a year ago, and 17 control subjects (untreated) who were living in the same area. Patients re...