The molecular chemistry of the f-elements, i.e. the lanthanides and actinides, is traditionally dominated by the use of carbon, nitrogen, oxygen or halide ligands. However, the use of metal-based fragments as ligands is underdeveloped, which contrasts to the field of d-block metal–metal complexes that have developed extensively over the last 50 years. Consequently, the use of metal-based fragme...

Pentavalent antimonial compounds have been the first line therapy for leishmaniasis; unfortunately the rate of treatment failure of anthroponotic cutaneous leishmaniasis (ACL) is increasing due to emerging of drug resistance. Elucidation of the molecular mechanisms operating in antimony resistance is critical for development of new strategies for treatment. Here, we used a cDNA-AFLP approach to...

In thecurrent research work,eleven metal complexes were synthesized from the hydrazide derivative of ursolic acid. Metal complexes of tin, antimony and iron were synthesized and characterized by FT-IR and NMR spectroscopy. The antibacterial and antioxidant activities were performed for these complexes, which revealed that the metal complexes synthesized are more potent than their parent compoun...

The aim of the present study was to evaluate the impact of a multiple dose regimen of a liposomal formulation of meglumine antimoniate (LMA) on the pharmacokinetics of antimony in the bone marrow of dogs with visceral leishmaniasis and on the ability of LMA to eliminate parasites from this tissue. Dogs naturally infected with Leishmania chagasi received 4 intravenous doses of either LMA (6.5 mg...

The growing resistance of leishmaniasis to first-line drugs like antimonials in some regions limits the control of this parasitic disease. The precise mechanisms involved in Leishmania antimony resistance are still subject to debate. The reduction of intracellular SbIII accumulation is a common change observed in both laboratory-selected and field isolated resistant Leishmania strains, but the ...

The present paper proposes an analytical procedure for speciation analysis of inorganic antimony in airborne particulate matter using slurry sampling and hydride generation atomic absorption spectrometry (HG QT AAS). During the antimony determination, a quartz T tube cell was heated to approximately 900 C using air–acetylene flame. The optimization step was performed by employing full two-level...

Two new antimony telluride single source precursors (SSPs), Ph2SbTeR (R = Et, Ph), have been used to synthesise pure and defect free hexagonal Sb2Te3 nanoplates by thermal decomposition in an organic solvent. The chemical composition of the SSPs plays an important role in the formation of antimony telluride nanocrystals.

Topological insulators exhibit a bulk energy gap and spin-polarized surface states that lead to unique electronic properties1–9, with potential applications in spintronics and quantum information processing. However, transport measurements have typically been dominated by residual bulk charge carriers originating from crystal defects or environmental doping10–12, and these mask the contribution...

Emergence of resistance to pentavalent antimonials has become a severe obstacle in the treatment of visceral leishmaniasis (VL) in the Indian subcontinent. Mitogen-activated protein kinases (MAPKs) are well-known mediators of signal transduction of eukaryotes, regulating important processes, like proliferation, differentiation, stress response, and apoptosis. In Leishmania, MAPK1 has been shown...